57357-56-9

Basic information

• Product Name: AC-D-NVA-OH
• Synonyms: N-ACETYL-D-NORVALINE;N-ALPHA-ACETYL-D-NORVALINE;ACETYL-D-NORVALINE;ACETYL-D-2-AMINOVALERIC ACID;AC-D-NVA-OH;(2R)-N-ACETYL-D-NORVALINE;(2R)-2-(Acetylamino)pentanoic acid;(R)-2-(Acetylamino)pentanoic acid
• CAS NO: 57357-56-9
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18
• Mol File: 57357-56-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.7 °C
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: AC-D-NVA-OH(CAS DataBase Reference)
• NIST Chemistry Reference: AC-D-NVA-OH(57357-56-9)
• EPA Substance Registry System: AC-D-NVA-OH(57357-56-9)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 57357-56-9(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C7H13NO3/c1-3-4-6(7(10)11)8-5(2)9/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m1/s1

Upstream product

• 60-35-5 acetamide 
• 504-61-0 (E)-but-2-enol 
• 201230-82-2 carbon monoxide 
• 627-27-0 homoalylic alcohol 
• 187737-37-7 propene 
• 760-78-1 2-aminopentanoic acid 
• 108-24-7 acetic anhydride 
• 1896-62-4 (E)-benzalacetone 
• 123-72-8 butyraldehyde 
• 106-88-7 ethyloxirane 
• 692-33-1 N-allylacetamide 
• 82518-89-6 acetylamino-propyl-malonic acid diethyl ester 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 7682-15-7 N-acetylnorvaline 

Downstream Products

• 2013-12-9 D-norvaline 
• 6600-40-4 L-Norvaline 
• 1575837-19-2 (3R,4R)-3-benzamido-2,5-dioxo-4-phenyl-3-propylpyrrolidin-1-yl acetate 
• 1242985-40-5 (R)-4-((S)-1-(furan-2-yl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1242985-41-6 (R)-4-((R)-3-oxo-1,3-diphenylpropyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1242985-37-0 (R)-4-((R)-1-(4-chlorophenyl)-3-oxobutyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 1242985-35-8 (R)-4-((R)-3-oxo-1-phenylbutyl)-2-phenyl-4-propyloxazol-5(4H)-one 
• 498-18-0 D-norvaline 
• 6600-40-4 L-norvaline 
• 399035-16-6 N-[1-(4-methyl-benzoyl)-butyl]-acetamide 

Relevant articles and documents

Efficient kinetic resolution of amino acids catalyzed by lipase AS 'Amano' via cleavage of an amide bond

Herein the efficient kinetic resolution of non-natural alpha-amino acids catalyzed by lipase AS 'Amano' via cleaving the amide bond is reported. The starting materials were the corresponding amino acid amides and the amino acids were generated with ees of up to 99% with E values of >600. These results indicated that the lipase AS 'Amano' could be a powerful amide hydrolase for the kinetic resolution of amino acid starting from the corresponding amino acid amides.

Palladium-catalyzed amidocarbonylation improved by recyclable ionic liquids

Two types of ionic liquids (halide anion ionic liquids and Brensted acidic ionic liquids) were first applied to improve the palladium-catalyzed amidocarbonylation. Both the palladium catalyst and the ionic liquids could be recycled at least five times without significant loss in catalytic activity. Georg Thieme Verlag Stuttgart.

Kinetic Resolution of Unnatural and Rarely Occuring Amino Acids: Enantioselective Hydrolysis of N-Acyl Amino Acids Catalyzed by Acylase I

Acylase I (aminoacylase; N-acylamino-acid amidohydrolase, EC 3.5.1.14, from porcine kidney and the fungus Aspergillus) is broadly applicable enzymatic catalyst for the kinetic resolution of unnatural and rarely occuring α-amino acids.Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality.This paper reports the initial rates of enzyme-catalyzed hydrolysis of over 50 N-acyl amino acids and analogues, the stabilities of the enzymes in aqueous and aqueous/organic solutions, and the effects of different acyl groups and metal ions on the rates of enzymatic hydrolysis.Eleven α-amino and α-methyl α-amino acids were resolved on a 2-29-g scale.Crude L- and D-amino acid products had generally >90percent ee.The utility of resolved amino acids as chiral synthons was illustrated by the preparation of (R)- and (S)-1-butene oxide and the diastereoselective (cis:trans, 7-8:1) iodolactonization of three 2-amino-4-alkenoic acid derivatives.