5736-89-0

Basic information

• Product Name: 4'-BUTOXYACETOPHENONE
• Synonyms: 1-(4-butoxyphenyl)-ethanon;Acetophenone, 4'-butoxy-;Ethanone, 1-(4-butoxyphenyl)-;1-(4-butoxyphenyl)ethan-1-one;Bufexamac Imp. (EP);4-(N-BUTOXY)ACETOPHENONE;4'-N-BUTOXYACETOPHENONE;4'-BUTOXYACETOPHENONE
• CAS NO: 5736-89-0
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• EINECS: 227-248-4
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Acetophenones (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;C11 to C12;Carbonyl Compounds;Ketones;Building Blocks;C11 to C12;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 5736-89-0.mol
• Article Data: 33

Chemical Properties

• Melting Point: 25-27°C
• Boiling Point: 302-304 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.017 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000888mmHg at 25°C
• Refractive Index: n20/D 1.531(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: very faint turbidity in Methanol
• BRN: 637894
• CAS DataBase Reference: 4'-BUTOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-BUTOXYACETOPHENONE(5736-89-0)
• EPA Substance Registry System: 4'-BUTOXYACETOPHENONE(5736-89-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 5736-89-0(Hazardous Substances Data)

Usage

Description

4'-BUTOXYACETOPHENONE, also known as 1-(4-butoxyphenyl)ethanone, is a mildly electron-enriched phenylmethylketone that exists as a colorless liquid. It is a useful research chemical with potential applications in various fields.

Uses

Used in Research and Development:
4'-BUTOXYACETOPHENONE is used as a research chemical for the synthesis of various compounds, including 3,5-di-(4-butoxyphenyl)-1H-pyrazole, (E)-1-(4-butoxyphenyl)-3-phenylprop-2-en-1-one, and 5-aryl-6H-1,3,4-thiadiazine. These synthesized compounds can be further explored for their potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4'-BUTOXYACETOPHENONE may be used as a key intermediate in the synthesis of various drugs and drug candidates. Its electron-enriched nature allows for the formation of new chemical entities with potential therapeutic properties.
Used in Chemical Synthesis:
4'-BUTOXYACETOPHENONE is used as a starting material or intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the development of new molecules with specific applications in various fields, such as materials science, agrochemicals, and specialty chemicals.

InChI:InChI=1/C12H16O2/c1-3-4-9-14-12-7-5-11(6-8-12)10(2)13/h5-8H,3-4,9H2,1-2H3

Upstream product

• 1126-79-0 n-butyl phenyl ether 
• 75-36-5 acetyl chloride 
• 99-93-4 4-Hydroxyacetophenone 
• 542-69-8 1-iodo-butane 
• 28530-37-2 1-butoxy-4-isopropylbenzene 
• 36160-80-2 1-butoxy-4-(1-methylpropyl)benzene 
• 99-71-8 4-(1-methylpropyl)phenol 
• 123-07-9 4-Ethylphenol 
• 99-89-8 4-Isopropylphenol 
• 2550-26-7 4-Phenyl-2-butanone 
• 105365-51-3 4-butoxyphenylboronic acid 
• 3524-86-5 1-(4-(4-bromobutoxy)phenyl)ethan-1-one 
• 69497-83-2 4-acetylphenyl mesylate 
• 71-36-3 butan-1-ol 

Downstream Products

• 24239-62-1 1-(4-butoxy-phenyl)-3-dimethylamino-propan-1-one; hydrochloride 
• 74980-02-2 1-(4-butoxy-phenyl)-3-diethylamino-propan-1-one; hydrochloride 
• 536-43-6 dyclonine HCl 
• 92595-22-7 [1-(4-Butoxy-phenyl)-eth-(E)-ylidene]-phenyl-amine 
• 93308-49-7 1-methyl-1-(4-butoxyphenyl)ethanol 
• 91763-92-7 1-(4-Butyloxy-phenyl)-ethanol-⁽¹⁾ 
• 115513-77-4 N-[1-(4-Butoxy-phenyl)-ethyl]-N-hydroxy-formamide 
• 642082-94-8 2-acetyl-4'-n-butoxyacetophenone 
• 6307-05-7 (E)-1-(4-butoxyphenyl)-3-phenylprop-2-en-1-one 
• 1243257-44-4 C₁₆H₂₅NO₃ 
• 1243257-35-3 2-[2-(4-butoxyphenylmorpholino-4-yl)ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate] hydrochloride 
• 1420891-07-1 3-(4-butoxyphenyl)-3-oxopropanal O-methyl oxime 
• 1420891-09-3 3-(4-butoxyphenyl)-3-oxopropanal O-ethyl oxime 

Relevant articles and documents

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Selective Activation of Unstrained C(O)-C Bond in Ketone Suzuki-Miyaura Coupling Reaction Enabled by Hydride-Transfer Strategy

A Rh(I)-catalyzed ketone Suzuki-Miyaura coupling reaction of benzylacetone with arylboronic acid is developed. Selective C(O)-C bond activation, which employs aminopyridine as a temporary directing group and ethyl vinyl ketone as a hydride acceptor, occurs on the alkyl chain containing a β-position hydrogen. A series of acetophenone products were obtained in yields up to 75%.

Site-Specific Oxidation of (sp3)C-C(sp3)/H Bonds by NaNO2/HCl

A site-specific oxidation of (sp3)C-C(sp3) and (sp3)C-H bonds in aryl alkanes by the use of NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as the solvent, and proceeds under mild conditions, making it valuable and attractive to synthetic organic chemistry.