573701-36-7

Basic information

• Product Name: Butanoic acid, 2-diazo-3-oxo-, (1R,2S)-2-[methyl(phenylmethyl)amino]-1-phenylpropyl ester
• CAS NO: 573701-36-7
• Molecular Formula: C21H23N3O3
• Molecular Weight: 365.432
• Mol File: 573701-36-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-diazo-3-oxo-, (1R,2S)-2-[methyl(phenylmethyl)amino]-1-phenylpropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-diazo-3-oxo-, (1R,2S)-2-[methyl(phenylmethyl)amino]-1-phenylpropyl ester(573701-36-7)
• EPA Substance Registry System: Butanoic acid, 2-diazo-3-oxo-, (1R,2S)-2-[methyl(phenylmethyl)amino]-1-phenylpropyl ester(573701-36-7)

Safety Data

• Hazardous Substances Data: 573701-36-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 90-85-7 (1R,2S)-1-phenyl-2-(N-methyl-N-benzylamino)propan-1-ol 
• 299-42-3 ephedrine 

Relevant articles and documents

Stereoselective formation and rearrangement of morpholinium ylides derived from copper carbenoids

Amino diazoacetoacetates 4a-e and 7a,b were prepared from readily available amino alcohols and subjected to copper-catalyzed carbene-transfer reaction. Substrates 4c-e furnished the morpholin-2-ones 5c-e in good yield via the corresponding cyclic ammonium ylides, albeit with poor diastereoselectivity. Substrates 4a,b failed to provide the corresponding morpholinones, perhaps as a result of steric congestion. Cyclic substrates 7a,b underwent conversion to bicyclic morpholinones 8 and 9 in good yield and with moderate to good diastereoselectivity. This result is rationalized via control of the transiently stereogenic ammonium center of the intermediate bicyclic ylides.