57382-97-5

Basic information

• Product Name: Ethyl 2-thiopheneacetate
• Synonyms: Thiophene-2-aceticacidethylester;Ethylthiophene-2-acetate,97%;Ethyl 2-thiopheneacetate,98%;ethyl 2-(thiophen-2-yl)acetate;Ethyl 2-thiopheneacetate 98%;2-THIENYLACETIC ACID, ETHYL ESTER;ETHYL 2-THIOPHENEACETATE;ETHYL THIOPHENE-2-ACETATE
• CAS NO: 57382-97-5
• Molecular Formula: C₈H₁₀O₂S
• Molecular Weight: 170.23
• EINECS: 260-715-0
• Product Categories: Thiophene&Benzothiophene;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiophenes
• Mol File: 57382-97-5.mol
• Article Data: 19

Chemical Properties

• Melting Point: 0.7 °C (approx)
• Boiling Point: 119-121 °C (23 mmHg)
• Flash Point: 104 °C
• Appearance: /
• Density: 1.134 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0841mmHg at 25°C
• Refractive Index: 1.509-1.511
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• BRN: 127918
• CAS DataBase Reference: Ethyl 2-thiopheneacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-thiopheneacetate(57382-97-5)
• EPA Substance Registry System: Ethyl 2-thiopheneacetate(57382-97-5)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 57382-97-5(Hazardous Substances Data)

Usage

Description

Ethyl 2-thiopheneacetate is a clear colorless to light yellow liquid that is utilized in the synthesis of various compounds and materials, particularly in the field of organic photovoltaic devices.

Uses

Used in Organic Photovoltaic Devices:
Ethyl 2-thiopheneacetate is used as a chemical precursor for the preparation of S-(2-(5-((amidinothio)methyl)-2-thienyl)ethyl)isothioureapyrrolo[3,2-b]pyrrole-based copolymers. These copolymers are essential components in the development of organic photovoltaic devices due to their ability to enhance the efficiency and performance of these devices by improving the charge transport and light absorption properties.

InChI:InChI=1/C8H10O2S/c1-2-10-8(9)6-7-4-3-5-11-7/h3-5H,2,6H2,1H3

Upstream product

• 20893-30-5 2-cyanomethylthiophene 
• 64-17-5 ethanol 
• 188290-36-0 thiophene 
• 623-48-3 ethyl iodoacetae 
• 64769-72-8 ethyl α-methylthio-2-thiopheneacetate 
• 6165-68-0 thiophene boronic acid 
• 105-36-2 ethyl bromoacetate 
• 765-50-4 2-Chloromethylthiophene 
• 1918-77-0 Thiophene-2-acetic acid 
• 1003-09-4 2-bromothiophene 
• 6148-64-7 ethyl potassium malonate 
• 186581-53-3 diazomethane 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 75-03-6 ethyl iodide 

Downstream Products

• 1918-77-0 Thiophene-2-acetic acid 
• 39978-18-2 2?(thiophen?2?yl)acetohydrazide 
• 83165-47-3 N-{2-[3-(2-Cyano-phenoxy)-2-hydroxy-propylamino]-ethyl}-2-thiophen-2-yl-acetamide 
• 5402-55-1 2-thiophenethanol 
• 943756-20-5 ethyl 5-tert-butyl-2-thienylacetate 
• 1610365-12-2 1,4-bis(4-(hexyloxy)phenyl)-3,6-di(thiophen-2-yl)pyrrolo[3,2-b]pyrrole-2,5(1H,4H)-dione 
• 1610365-09-7 1,4-diphenyl-3,6-di(thiophen-2-yl)pyrrolo[3,2-b]pyrrole-2,5(1H,4H)-dione 
• 39098-97-0 2-thienylacetic acid chloride 
• 1126-93-8 2-ethoxy-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 376584-72-4 3-(3,4-dichloro-phenyl)-2-thiophen-2-yl-propionic acid 

Relevant articles and documents

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A novel method for the synthesis of 1,2,4-triazole-derived heterocyclic compounds: enzyme inhibition and molecular docking studies

Two series of new N-aryl/aralkyl derivatives (9a–q) of 2-(4-ethyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide and N-aryl/aralkyl derivatives (10a–q) of 2-(4-phenyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide were synthesized. The methods included successive conversions of thiophen-2-acetic acid (a) into its respective ester, hydrazide and N-aryl/aralkyl 1,3,4-triazole. The target compounds (9a–q; 10a–q) were obtained by the reaction of N-aryl/aralkyl 1,3,4-triazole (5, 6) with various electrophiles, (8a–q), in N,N-dimethyl formamide (DMF) and sodium hydroxide at room temperature. The characterization of these compounds was done by FTIR, 1H-, 13C-NMR, EI-MS and HR-EI-MS spectral data. All compounds were evaluated for their enzyme inhibitory potentials against electric eel acetylcholinesterase, AChE (10f, 10d; IC50 values 32.26 ± 0.12, 45.72 ± 0.11?μM, respectively), equine butyrylcholinesterase, BChE (9d, 9l, 9b, 10d, 10h; IC50 values 12.52 ± 0.19, 12.52 ± 0.19, 21.72 ± 0.18, 23.62 ± 0.22, 24.52 ± 0.21?μM, respectively), jack bean urease (10i, 10n, 9e; IC50 values 7.27 ± 0.05, 7.35 ± 0.04, 8.79 ± 0.05?μM, respectively) and yeast α-glucosidase enzymes (9o, 10i; IC50 values 62.94 ± 0.19, and 69.46 ± 0.15?μM, respectively). The molecular docking studies supported these findings. This study provides cheaper bioactive triazole amides as promising future lead molecules.

Compounding method for 2-thiopheneacetyl chloride

The invention discloses a compounding method for 2-thiopheneacetyl chloride and belongs to the technical field of organic synthesis. The 2-thiopheneacetyl chloride is compounded by taking thiophene asa raw material through following three-step reaction: 1) acquiring 2-thiophene acetate through the F-C reaction of thiophene and glycolate under the existence of catalyst; 2) hydrolyzing the 2-thiophene acetate under the existence of acid, thereby acquiring 2-thiopheneacetic acid; 3) treating the 2-thiopheneacetic acid in the manner of acylating chlorination with thionyl chloride under the catalysis of pyridine, thereby acquiring 2-thiopheneacetyl chloride. The compounding method for 2-thiopheneacetyl chloride has the characteristics of easily acquired raw materials and simple and convenientoperation and is suitable for industrial production.