57564-91-7 Usage
Description
S-Nitroso-L-glutathione (GSNO) is an S-nitrosothiol NO donor based on naturally-occurring glutathione. It is a potent smooth muscle relaxant and inhibitor of platelet aggregation. Its stability in solution varies from seconds to hours depending on temperature, buffer composition, and metal content. GSNO is a pink powder that serves as a utility carrier of nitric oxide, breaking down at physiological pH to produce nitric oxide. It also induces apoptosis in mouse thymocytes.
Uses
1. As a carrier of nitric oxide, GSNO is used for relaxing smooth muscle and inhibiting platelet activation, which can be beneficial in various medical applications related to cardiovascular health and blood clotting.
2. In Analytical Chemistry:
S-Nitrosoglutathione (GSNO) is used as a standard in reversed phase chromatography coupled to chemical vapour generation and atomic fluorescence detector (RPC-CVGAFS) and reversed phase chromatography fluorimetric (RPC-FD). This application helps in the accurate detection and quantification of GSNO in various samples.
3. In Spectrophotometric and High-Performance Liquid Chromatography (HPLC) Assay:
GSNO is utilized as a standard in spectrophotometric and HPLC assays, allowing for the precise measurement and analysis of its concentration in different solutions and experiments.
Biological Activity
A carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation.
Biochem/physiol Actions
Product does not compete with ATP.
Check Digit Verification of cas no
The CAS Registry Mumber 57564-91-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,5,6 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 57564-91:
(7*5)+(6*7)+(5*5)+(4*6)+(3*4)+(2*9)+(1*1)=157
157 % 10 = 7
So 57564-91-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/p-1/t5-,6-/m0/s1
57564-91-7Relevant articles and documents
Equilibrium and kinetics studies of transnitrosation between S-nitrosothiols and thiols
Wang, Kun,Wen, Zhong,Zhang, Wei,Xian, Ming,Cheng, Jin-Pei,Wang, Peng George
, p. 433 - 436 (2007/10/03)
Using UV-vis spectrometrical measurements, equilibrium constants for NO transfer between S-nitroso-N-acetyl-penicillamine (SNAP) and different thiols as well as kinetic data for NO transfer from S-nitroso bovine serum albumin (BSANO) to thiols have been obtained. NO transfer from SNAP to other primary/secondary thiols are thermodynamically favorable, whereas other S-nitrosothiols exhibit similar NO transfer potential. The obtained Gibbs free energy, enthalpy and entropy data indicated that NO transfer reactions from SNAP to four thiols are exothermic with entropy loss. The kinetic behavior of BSANO/RSH transfer can be related to both the acidity of sulfhydryl group and the electronic structure in thiol.
