57625-49-7Relevant articles and documents
Microwave-enhanced reactions under open and closed vessel conditions. A case study
Stadler, Alexander,Pichler, Sonja,Horeis, Gabriela,Kappe, C.Oliver
, p. 3177 - 3183 (2002)
Important differences have been observed when performing microwave-enhanced organic transformations, using open and closed vessel conditions. For the hydrolysis of benzamide with sulfuric acid in sealed vessels, where no volatile products are formed, no appreciable difference in reaction performance as a function of the filling volume of the vials or the reaction scale were detected. However, in the cyclocondensation of tetrahydroquinoline with substituted malonic esters, where 2equiv. of ethanol are formed, the outcome of the reaction under sealed vessel conditions is critically dependent on the scale of the reaction.
Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions
Lange, Jos H.M.,Verveer, Peter C.,Osnabrug, Stefan J.M.,Visser, Geb M.
, p. 1367 - 1369 (2007/10/03)
3-Aryl-4-hydroxyquinolin-2(1H)-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolinones ar
Synthesis of Benzofuranes by Cyclodehydrogenation of Phenylmalonyl Heterocyclic Compounds
Stadlbauer, Wolfgang,Schmut, Otto,Kappe, Thomas
, p. 1005 - 1014 (2007/10/02)
Phenylmalonyl heterocyclic compounds such as the quinolones 1a-c or 3, benzoquinolizinones 6a, b and the phenalenones 8a, b can be converted to benzofuranes (2a-c, 7a, b and 9a, b) by cyclodehydrogenation with Pd/C in boiling diphenyl ether. 2-Phenylchinc