57648-83-6

Basic information

• Product Name: 3-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PROPAN-1-AMINE
• Synonyms: 3-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PROPAN-1-AMINE
• CAS NO: 57648-83-6
• Molecular Formula: C₁₁H₁₉N₅
• Molecular Weight: 221.3
• Mol File: 57648-83-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PROPAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PROPAN-1-AMINE(57648-83-6)
• EPA Substance Registry System: 3-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PROPAN-1-AMINE(57648-83-6)

Safety Data

• Hazardous Substances Data: 57648-83-6(Hazardous Substances Data)

Upstream product

• 138274-09-6 3-(4-(pyrimidin-2-yl)piperazin-1-yl)propanenitrile 
• 20980-22-7 N-(2-pyridinyl)piperazine 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 206053-35-2 [3-(4-Pyrimidin-2-yl-piperazin-1-yl)-propyl]-carbamic acid tert-butyl ester 
• 78069-54-2 1-(2-pyrimidinyl)piperazine hydrochloride 

Downstream Products

• 1227151-28-1 C₂₈H₃₀N₈ 
• 1227151-29-2 C₂₇H₂₇BrN₈ 
• 1227151-30-5 C₂₇H₂₇ClN₈ 
• 1227151-31-6 C₂₇H₂₇FN₈ 
• 1227151-32-7 C₂₈H₂₇N₉ 
• 1227151-33-8 C₂₇H₂₇N₉O₂ 
• 1227151-49-6 C₂₅H₃₀N₈ 
• 1227151-50-9 C₂₅H₂₉ClN₈ 
• 1227151-51-0 C₂₅H₂₉FN₈ 
• 1227151-52-1 C₂₅H₂₉N₉O₂ 

Relevant articles and documents

Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D4 Receptor Agonists with High Subtype Selectivity

Many subtype-selective dopamine receptor ligands developed for the D2-D4 family incorporate a 1-arylpiperazine-derived primary recognition motif, which is connected to a lipophilic moiety occupying an extended binding pocket (EBP) of the receptor via an aliphatic linker of variable lengths. The evaluation of a novel group of dopamine receptor ligands now showed that highly subtype-selective ligands [up to Ki(D4.4) = 0.25 nM, D2L/D4.4 = 320, D3/D4.4 = 710 for APH199 (17)] can be obtained by choosing a relatively large and conformationally flexible 1-benzyl-1-phenylsemicarbazide substructure to fill the EBP. The novel chemotype APH199 (17) was found to act as a full agonist at the D4 receptor showing significant bias toward G protein activation over β-arrestin recruitment in comparison to quinpirole.

5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: Novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity

The vacuolar H+-ATPase (V-ATPase), located on the ruffled border of the osteoclast, is a proton pump which is responsible for secreting the massive amounts of protons that are required for the bone resorption process. With the aim to identify n

Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-b icyclo[2.2.1]heptanedicarboxime (Tandospirone) and related compounds

A series of cyclic imides bearing a ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT(1A) receptor sites. Structure-activity relationships within these series are discussed. One of these compounds, (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (1: tandospirone), was found to be equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. Tandospirone (1) is currently undergoing clinical evaluation as a selective anxiolytic agent.