57709-82-7

Basic information

• Product Name: Benzamide, N-(2-hydroxyphenyl)-4-methyl-
• Synonyms: 2-p-Toluoylamino-phenol
• CAS NO: 57709-82-7
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Mol File: 57709-82-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 135 °C(Solv: benzene (71-43-2))
• Boiling Point: 307.0±35.0 °C(Predicted)
• Density: 1.241±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzamide, N-(2-hydroxyphenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-hydroxyphenyl)-4-methyl-(57709-82-7)
• EPA Substance Registry System: Benzamide, N-(2-hydroxyphenyl)-4-methyl-(57709-82-7)

Safety Data

• Hazardous Substances Data: 57709-82-7(Hazardous Substances Data)

Upstream product

• 13787-59-2 3-benzoyl-2(3H)-benzoxazolone 
• 6749-78-6 4-methylphenylmagnesium iodide 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 95-55-6 2-amino-phenol 
• 99-94-5 p-Toluic acid 
• 93099-43-5 2-nitrophenyl 4-methylbenzylether 

Downstream Products

• 132283-34-2 C₂₀⁽¹³⁾CH₁₇NO₃ 
• 835-71-2 2-(4-methylphenyl)-1,3-benzoxazole 
• 97971-79-4 N,O-di(p-toluoyl)-o-aminophenol 
• 97971-77-2 N-(p-toluoyl)-O-(1-naphthoyl)-o-aminophenol 
• 58758-38-6 4-phenyl-2-p-tolylbenzo[d]oxazole 

Relevant articles and documents

Immobilized Carbodiimide Assisted Flow Combinatorial Protocol to Facilitate Amide Coupling and Lactamization

Through a screen of over one hundred and 30 permutations of reaction temperatures, solvents, carbodiimide resins, and carbodiimide molar equivalences, in the presence, absence, or combination of diisopropylamine and benzotriazole additives, a convenient and first reported carbodiimide polymer-assisted flow approach to effect amide coupling and lactamization was developed. The protocol entails injecting a single solution (1:9 dimethylformamide: dichloromethane) containing a carboxylic acid and an amine or linear peptide sequence into a continuous stream of dichloromethane. The protocol remained viable in the absence of base, did not require carboxylate preactivation which, and in concert with minimal workup requirements, enabled the isolation of products in high yields. Compared to the utilization of untethered carbodiimide reagents, the flow procedure was also observed to provide a degree of racemization safety.

Synthesis, antimicrobial, and QSAR studies of substituted benzamides

A series of new substituted benzamides were synthesized and tested in vitro for their antibacterial activity against Gram-positive and Gram-negative bacteria and as well for antifungal activity. The compounds 8i and 9 showed better activity among the different benzamides synthesized. The structural characteristics governing antibacterial activities of substituted benzamides were studied using QSAR methodology. The results showed that the antimicrobial activity could be modeled using the topological descriptors, molecular connectivity indices (2χv and 2χ) and Kiers shape index (κα1). The low residual activity and high cross-validated r2 values (rcv2) observed indicated the predictive ability of the developed QSAR models.

Hypervalent iodine in synthesis 69: An efficient synthesis of 2-arylbenzoxazoles via the palladium-catalysed carbonylation and condensation of diaryliodonium salts and o-aminophenols

An efficient synthetic method is reported in which 2-arylbenzoxazoles have been prepared in good to excellent yields under mild reaction conditions by the palladium-catalysed carbonylation of diaryliodonium salts with o-aminophenols followed by dehydrative cyclisation.