57765-24-9

Basic information

• Product Name: 6-BENZYLOXYINDOLE-3-ACETONITRILE
• Synonyms: 6-BENZYLOXYINDOLE-3-ACETONITRILE;6-(PhenylMethoxy)-1H-indole-3-acetonitrile;2-(6-(Benzyloxy)-1H-indol-3-yl)acetonitrile
• CAS NO: 57765-24-9
• Molecular Formula: C₁₇H₁₄N₂O
• Molecular Weight: 262.31
• Product Categories: Aromatic Nitriles;Aromatics;Indole Derivatives;Intermediates
• Mol File: 57765-24-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 130-133°C
• Boiling Point: 502.3 °C at 760 mmHg
• Flash Point: 257.6 °C
• Appearance: /
• Density: 1.232 g/cm³
• PKA: 16.48±0.30(Predicted)
• CAS DataBase Reference: 6-BENZYLOXYINDOLE-3-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYLOXYINDOLE-3-ACETONITRILE(57765-24-9)
• EPA Substance Registry System: 6-BENZYLOXYINDOLE-3-ACETONITRILE(57765-24-9)

Safety Data

• Hazardous Substances Data: 57765-24-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Crystalline Solid

Uses

A hydroxytryptamine

Upstream product

• 57765-22-7 3-(dimethylaminomethyl)-6-benzyloxyindole 
• 15903-94-3 6-benzyloxy-1H-indole 
• 629662-36-8 (6-benzyloxy-1H-indol-3-ylmethyl)trimethylammonium iodide 
• 773837-37-9 sodium cyanide 
• 92855-64-6 6-benzyloxy-1H-indole-3-carboxaldehyde 
• 40047-21-0 (4-benzyloxy-2-nitro-phenyl)-pyruvic acid 
• 40047-22-1 6-(benzyloxy)-1H-indole-2-carboxylic acid 

Downstream Products

• 443-31-2 6-hydroxytryptamine 
• 57765-25-0 C₁₈H₁₆N₂O 
• 1447648-40-9 C₁₉H₁₆N₂O₂ 
• 1447648-42-1 C₁₉H₁₆N₂O₃ 
• 1447648-54-5 C₂₀H₁₈N₂O₃ 
• 31677-74-4 2-(6-benzyloxy-indol-3-yl)-ethylamine 

Relevant articles and documents

Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells

Arvelexin is one of major constituents of Brassica rapa that exerts anti-inflammatory activities. Several indolyl-3-acetonitrile derivatives were synthesized as arvelexin analogs and evaluated for their abilities to inhibit NO and PGE2 productions in LPS-induced RAW 264.7 cells. Of the indolyl-3-acetonitriles synthesized, compound 2k, which possesses a hydroxyl group at C-7 position of the indole ring and an N-methyl substituent, more potently inhibited NO and PGE2 productions and was less cytotoxic than arvelexin on macrophage cells.

AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS

The present invention is directed to compounds of formula (I) and formula (II): formula (I) and (II), wherein R1-R8, A and n are as described in the description. These compounds are used in pharmaceutical compositions and methods for modulating the activity of orphan nuclear receptors.