582-54-7

Basic information

• Product Name: 2,5-dichlorophenoxyacetic acid
• Synonyms: (2,5-dichlorophenoxy)acetic acid(SALTDATA: FREE);(2,5-Dichlorophenoxy)acetic acid AldrichCPR;(2,5-Diclorophenoxy)acetic acid;2-(2,5-dichlorophenoxy)ethanoic acid;Acetic acid, (2,5-dichlorophenoxy)-;Acetic acid, (2,5-dichlorophenoxy)- (8CI)(9CI);EINECS 209-487-6;NSC 190556
• CAS NO: 582-54-7
• Molecular Formula: C₈H₆Cl₂O₃
• Molecular Weight: 221.04
• EINECS: 209-487-6
• Mol File: 582-54-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 316.96°C (rough estimate)
• Flash Point: 161.2°C
• Appearance: /
• Density: 1.4564 (rough estimate)
• Vapor Pressure: 2.78E-05mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Water Solubility: 534.9mg/L(25 oC)
• CAS DataBase Reference: 2,5-dichlorophenoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dichlorophenoxyacetic acid(582-54-7)
• EPA Substance Registry System: 2,5-dichlorophenoxyacetic acid(582-54-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 582-54-7(Hazardous Substances Data)

Usage

Description

2,5-Dichlorophenoxyacetic acid, commonly known as 2,4-D, is a synthetic auxin herbicide and plant growth regulator. It is widely used in agriculture to control broadleaf weeds in crops and turf by mimicking the natural hormone indole-3-acetic acid, causing uncontrolled growth and ultimately leading to plant death. Being water-soluble, its environmental persistence is influenced by factors such as soil type and climate. While it has faced scrutiny for potential health and environmental impacts, including links to certain cancers and effects on non-target species, 2,4-D continues to be one of the most prevalent herbicides globally.

Uses

Used in Agricultural Industry:
2,4-D is used as a herbicide for controlling broadleaf weeds in various crops and turf. It functions by mimicking the natural plant hormone indole-3-acetic acid, leading to uncontrolled growth and death of the targeted weeds, thus improving crop yield and maintaining the quality of turf areas.
Used in Plant Growth Regulation:
In addition to its herbicidal properties, 2,4-D is also used as a plant growth regulator. It can influence the growth patterns of certain plants, making it a valuable tool in horticulture and agriculture for managing plant development and shaping landscapes.
Despite its widespread use, it is important to consider the potential health and environmental effects associated with 2,4-D, such as its association with certain types of cancer and its impact on non-target plants and animals. This necessitates responsible use and ongoing research into safer alternatives or methods to mitigate its environmental impact.

InChI:InChI=1/C8H6Cl2O3/c9-5-1-2-6(10)7(3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 2009-15-6 2,5-Dichlorphenoxyessigsaeure-methylester 
• 583-78-8 2,5-dichlorophenol 
• 93-76-5 2,4,5-Trichlorophenoxyacetic acid 
• 92696-68-9 tert-butyl 2-(2,5-dichlorophenoxy)acetate 
• 79-11-8 chloroacetic acid 
• 32026-07-6 (2,5-dichloro-phenoxy)-acetic acid amide 
• 61763-88-0 (2,5-dichloro-phenoxy)-acetic acid ethyl ester 

Downstream Products

• 1445980-92-6 1-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)-2-(2,5-dichlorophenoxy)ethanone trifluoroacetate 
• 16429-74-6 1-[(2,5-dichloro-phenoxy)-acetyl]-1H-benzoimidazole 
• 6467-26-1 2,5-Dichlor-4-<2-methylen-butyryl>-phenoxyessigsaeure 
• 61763-88-0 (2,5-dichloro-phenoxy)-acetic acid ethyl ester 
• 55502-51-7 (2,5-dichloro-phenoxy)-acetyl chloride 
• 93-76-5 2,4,5-Trichlorophenoxyacetic acid 

Relevant articles and documents

Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our previous lead optimization efforts, we have identified a new ether-based scaffold and paired this with a novel sulfone-based head group to identify a potent and selective GIRK1/2 activator. In addition, we evaluated the compounds in tier 1 DMPK assays and have identified compounds that display nanomolar potency as GIRK1/2 activators with improved metabolic stability over the prototypical urea-based compounds. This journal is

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.

NON-SYSTEMIC TGR5 AGONISTS

Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.