58246-80-3

Basic information

• Product Name: 1-Acetyl-5-methoxyindole
• Synonyms: Acetyl-5-methoxy indole;1-Acetyl-5-methoxy indole;1-(5-Methoxy-1H-indol-1-yl)ethanone
• CAS NO: 58246-80-3
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 58246-80-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 306.164ºC at 760 mmHg
• Flash Point: 138.963ºC
• Appearance: /
• Density: 1.144g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Acetyl-5-methoxyindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-5-methoxyindole(58246-80-3)
• EPA Substance Registry System: 1-Acetyl-5-methoxyindole(58246-80-3)

Safety Data

• Hazardous Substances Data: 58246-80-3(Hazardous Substances Data)

Usage

General Description

1-Acetyl-5-methoxyindole is a chemical compound categorized as an indole, a group known for versatility in producing biologically active molecules. Its structure consists of a benzene ring fused to a pyrrole ring, with additional acetyl and methoxy functional groups, contributing to its varying properties. 1-Acetyl-5-methoxyindole serves as a crucial building block in chemical synthesis and drug discovery, often applied in medicinal chemistry and pharmaceutical industries. The properties, reactivity, and applications of 1-Acetyl-5-methoxyindole greatly depend on its structural features and the modifications brought about by its functional groups.

InChI:InChI=1/C11H11NO2/c1-8(13)12-6-5-9-7-10(14-2)3-4-11(9)12/h3-7H,1-2H3

Upstream product

• 127-09-3 sodium acetate 
• 108-24-7 acetic anhydride 
• 872-36-6 vinylene carbonate 
• 51-66-1 4-methoxyacetanilide 
• 1006-94-6 5-methoxylindole 
• 108-05-4 vinyl acetate 
• 90271-35-5 2-amino-5-methoxy-benzaldehyde-oxime 
• 74054-28-7 N-(2-bromo-5-methoxyphenethyl)acetamide 
• 36688-73-0 N-(3-methoxyphenylethyl)acetamide 
• 79069-37-7 1-(acetamino)-2-bromo-4-methoxybenzene 
• 84689-22-5 2,4,6-Trimethyl-benzenesulfonate1-amino-6-methoxy-2-methyl-quinolinium; 
• 1078-28-0 6-methoxyquinaldine 
• 78827-69-7 C₁₄H₁₆N₂O₃ 
• 78827-74-4 7-Methoxy-2-methyl-benzo[d][1,3]diazepine-3-carboxylic acid ethyl ester 

Downstream Products

• 1235306-53-2 2-(2',4'-dimethoxyphenyl)-5-methoxy-N-acetylindole 
• 54888-61-8 5-methoxy-2-phenyl-2,3-dihydro-indole 
• 1224728-83-9 C₁₈H₁₇NO₃ 
• 942924-10-9 1-(5-methoxy-2-phenyl-1H-indol-1-yl)ethan-1-one 
• 942924-01-8 1-(5-methoxy-3-phenyl-1H-indol-1-yl)ethan-1-one 
• 1006-94-6 5-methoxylindole 

Relevant articles and documents

Formation of 3H-1,3-Benzodiazepines from Quinoline N-Acylimides

Photolysis of the quinoline N-imides (3) having an electron-donating substituent in the 6- or 8-position affords the corresponding 3H-1,3-benzodiazepines (4), whereas quinolines having an electron-donating group in the other positions or an electron-withd

Na 2 CO 3-Catalyzed N-Acylation of Indoles with Alkenyl Carboxylates

The N-acylation of indoles has been accomplished via inorganic base catalysis. It provided an efficient and simple catalysis system for the preparation of N-acylindoles with alkenyl carboxylates as acylating agents. A broad variety of indoles undergo the smooth N-acylation using Na 2 CO 3 as catalyst in MeCN at 120? °C to give the corresponding N-acylindoles in good to excellent yields.

Based on carboxylic acid allyl ester as the acylation reagent N - acyl indoles preparation method (by machine translation)

Based on carboxylic acid allyl ester as the acylation reagent N - acyl indoles preparation method, which belongs to the medical and chemical intermediates and related chemical technical field. This method uses the indole compounds and carboxylic acid allyl ester as the raw material, in the catalysis of alkali, realizes the N - acyl indoles of green, efficient synthesis. The method has high selectivity, mild reaction conditions, functional group compatibility is good, wide substrate range, environment-friendly and the like. Because the N - acyl indoles is an important organic synthetic intermediates, in organic synthesis and in the field of pharmacy has very wide application, therefore, the invention has great application value and social and economic benefits. (by machine translation)