58320-73-3Relevant articles and documents
Post-modification of helical dipeptido polyisocyanides using the 'click' reaction
Kitto, Heather J.,Schwartz, Erik,Nijemeisland, Marlies,Koepf, Matthieu,Cornelissen, Jeroen J. L. M.,Rowan, Alan E.,Nolte, Roeland J. M.
, p. 5615 - 5624 (2008)
Polyisocyanopeptides have been synthesised containing acetylene groups on the side arms as scaffolds for multifunctional derivatisation by the copper-catalysed click reaction with a variety of azides. By using ethylene glycol azide and perylene azide chro
Luminescent gels by self-assembling platinum complexes
Allampally, Naveen Kumar,Strassert, Cristian A.,De Cola, Luisa
, p. 13132 - 13137 (2012)
A platinum complex bearing a tetraethylene glycol chain has been designed and its self-assembly properties investigated. In solution, only a yellow phosphorescence of the aggregated species is observed. The complex gives luminescent gels of different colo
Chirality Synchronization of Hydrogen-Bonded Complexes of Achiral N-Heterocycles
Buchs, Jens,Vogel, Laura,Janietz, Dietmar,Prehm, Marko,Tschierske, Carsten
, p. 280 - 284 (2017)
2,4-Diamino-6-phenyl-1,3,5-triazines carrying a single oligo(ethylene oxide) (EO) chain form an optically isotropic mesophase composed of a conglomerate of macroscopic chiral domains with opposite sense of chirality even though the constituent molecules are achiral. This mesophase was proposed to result from the helical packing of hydrogen-bonded triazine aggregates, providing long-range chirality synchronization. The results provide first evidence for macroscopic achiral symmetry breaking upon conglomerate formation in an amorphous isotropic phase formed by hydrogen-bonded associates of simple N-heterocycles that are related to prebiotic molecules.
TPE based aggregation induced emission fluorescent sensors for viscosity of liquid and mechanical properties of hydrogel
Wang, Na,Yao, Hang,Tao, Qi,Sun, Jing,Ma, Hao,Wang, Yang,Zhou, ChengCheng,Fan, Hongying,Shao, Hongxia,Qin, Aijian,Su, Dawei,Wang, Chenyin,Chong, Hui
supporting information, p. 252 - 256 (2021/08/13)
Two amphiphilic TPE E/Z isomers with aggregation induced emission (AIE) property have been synthesized and characterized. The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid. To note
Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors
Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu
supporting information, p. 1481 - 1496 (2021/02/27)
CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.
Construction of Janus dendrimers through a self-assembly approach involving chiral discrimination at a focal point
Zhou, John,Cole, Ashley M.,Menuey, Elizabeth M.,Kilway, Kathleen V.,Moteki, Shin A.
supporting information, p. 6404 - 6407 (2021/07/02)
A strategy to build Janus dendrimersviathe chirality-directed self-assembly of heteroleptic Zn(ii) BOX complexes is reported. The method allows quantitative synthesis of Janus dendrimersin situwithout the need for purifications. Each dendritic domain of t
