58369-46-3Relevant articles and documents
Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1
Konno, Hiroyuki,Endo, Hitoshi,Ise, Satomi,Miyazaki, Keiki,Aoki, Hideo,Sanjoh, Akira,Kobayashi, Kazuya,Hattori, Yasunao,Akaji, Kenichi
supporting information, p. 685 - 690 (2014/01/23)
To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity. The structure-activity relationship study of curcumin derivatives is described. Our results indicate that phenolic hydroxy groups and an alkenyl spacer are important structural factors for the inhibition of beta-site amyloid precursor protein cleaving enzyme 1 and, furthermore, non-competitive inhibition of enzyme activity is anticipated from an inhibitory kinetics experiment and docking simulation.
On regioselectivity of aldol condensation of aromatic aldehydes with borate complex of acetylacetone
Martichonok, Val V.,Chiang, Peter K.,Dornbush, Padraick J.,Land, Kirkwood M.
, p. 1245 - 1250 (2014/04/17)
While cinnamoyl acetone 1 is obtained in good yield by a condensation of 3 molar excess of a borate complex of acetylacetone with benzaldehyde, products of Knoevenagel condensation 2 are predominantly obtained with furfural and 5-substituted furfurals. Cinnamoyl acetone 1 can be further condensed with furfural to form unsymmetrical curcuminoid 5. Compound 2a does not produce any new products under the same conditions. Compounds 3 and 5 are good inhibitors of growth of protozoan Trichomonas vaginalis.
Metal chelates of 6-aryl-5-hexene-2,4-diones
Venugopalan,Krishnankutty
, p. 472 - 473 (2007/10/03)
A series of 6-aryl-5-hexene-2,4-diones and their NiII, CuII, ZnII and PdII chelates of composition ML2 have been synthesised. The metal ion replaces the enol proton of the ligands with the formation o