58417-55-3Relevant articles and documents
Oxidant-Mediated Nitrogenation and Recyclization of Imidazo[1,2-a]pyridines with Sodium Azide: Synthesis of 4H-Pyrido[1,2-a][1,3,5]triazin-4-ones
Cao, Gangjian,Chen, Zhengkai,Song, Jinyu,Xu, Jianfeng,Miao, Maozhong,Ren, Hongjun
, p. 881 - 886 (2018)
An expeditious and straightforward approach for the synthesis of 4H-pyrido[1,2-a][1,3,5]triazin-4-ones starting from readily available imidazo[1,2-a]pyridines and sodium azide has been presented under aerobic oxidative conditions. The reaction proceeded well with the promotion of potassium persulfate/potassium permanganate with good functional group tolerance. A wide range of biologically valuable 4H-pyrido[1,2-a][1,3,5]triazin-4-one scaffolds were assembled by this methodology. The gram-scale reaction was also achieved. A cascade nitrogenation and oxidative recyclization sequence could be involved in the reaction. (Figure presented.).