585-45-5

Basic information

• Product Name: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane
• CAS NO: 585-45-5
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.1725
• Mol File: 585-45-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 246.9°C at 760 mmHg
• Flash Point: 110.2°C
• Density: 1.304g/cm³
• Vapor Pressure: 0.0416mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane(585-45-5)
• EPA Substance Registry System: 2-{[3-(trifluoromethyl)phenoxy]methyl}oxirane(585-45-5)

Safety Data

• Hazardous Substances Data: 585-45-5(Hazardous Substances Data)

Usage

Chemical compound

Epoxide with a trifluoromethyl group and a phenoxy group attached to the oxirane ring

Also known as

Trifenagrel and CVN162

Potential therapeutic effects

Treatment of thrombosis and other cardiovascular conditions

Mechanism of action

Potent and selective antagonist of the platelet P2Y12 receptor

Role in platelet aggregation

Inhibits blood clot formation

Potential application

Development of antithrombotic drugs

Research status

Further evaluation needed for efficacy and safety in clinical use

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 106-89-8 epichlorohydrin 

Downstream Products

• 5214-61-9 1-(Methyl-benzylamino)-3-(3-trifluormethyl-phenoxy)-propanol-⁽²⁾ 
• 54094-19-8 dimethyl [3-(3-(trifluoromethyl)phenoxy)-2-oxopropyl]phosphonate 
• 5002-97-1 N-Methyl-2-hydroxy-3-(m-trifluormethylphenoxy)-propylamin 
• 1224936-56-4 C₁₉H₂₀F₃NO₂ 
• 1224936-53-1 C₁₆H₂₂F₃NO₃ 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Cu-Catalyzed cross-coupling reactions of epoxides with organoboron compounds

A copper-catalyzed cross-coupling reaction of epoxides with arylboronates is described. This reaction is not limited to aromatic epoxides, because aliphatic epoxides are also suitable substrates. In addition, N-sulfonyl aziridines can be successfully converted into the products. This reaction provides convenient access to β-phenethyl alcohols, which are valuable synthetic intermediates.

ANALGESIC THAT BINDS FILAMIN A

A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within.