58560-71-7

Basic information

• Product Name: [S,(-)]-1-O,2-O-Dipalmitoyl-D-glycerol 3-phosphoric acid
• Synonyms: [S,(-)]-1-O,2-O-Dipalmitoyl-D-glycerol 3-phosphoric acid
• CAS NO: 58560-71-7
• Molecular Formula: C35H69O8P
• Molecular Weight: 648.89
• Mol File: 58560-71-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [S,(-)]-1-O,2-O-Dipalmitoyl-D-glycerol 3-phosphoric acid(CAS DataBase Reference)
• NIST Chemistry Reference: [S,(-)]-1-O,2-O-Dipalmitoyl-D-glycerol 3-phosphoric acid(58560-71-7)
• EPA Substance Registry System: [S,(-)]-1-O,2-O-Dipalmitoyl-D-glycerol 3-phosphoric acid(58560-71-7)

Safety Data

• Hazardous Substances Data: 58560-71-7(Hazardous Substances Data)

Upstream product

• 6076-30-8 1,2-di-O-palmitoyl-sn-glycerol 
• 30563-16-7 2,3-dipalmitoyl-1-triphenylmethyl-sn-glycerol 

Downstream Products

• 115290-75-0 C₄₄H₇₉N₃O₁₅P₂^(2-)*2Na⁽¹⁺⁾ 

Relevant articles and documents

Nucleoside conjugates. 10. Synthesis and antitumor activity of 1-β-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitins

Three 1-β-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitins from L-, D- and DL-α-dipalmitoylphosphatidic acids have been synthesized and their antitumor activity against two ara-C2 resistant L1210 lymphoid leukemia sublines in mice were evaluated. These new prodrugs of ara-C include ara-CDP-L-dipalmitin (1), ara-CDP-D-dipalmitin (2), and ara-CDP-DL-dipalmitin (3). The L and DL isomers produced significant increase in life span (>400%) and four to five long-term survivors (>45 days) out of six animals bearing ip implanted partially ara-C resistant L1210 subline [L1210/ara-C (I)], while the D isomer displayed a marginal activity (ILS 100-121%). In contrast, the L isomer was completely ineffective against deoxycytidine kinase deficient ara-C resistant L1210 subline [L1210/ara-C (II)]. However, the results demonstrate that the L and DL isomers of ara-CDP-dipalmitin are promising new prodrugs of ara-C with improved efficacy.