588703-29-1Relevant articles and documents
Method for preparing benzo oxygen-containing aliphatic heterocyclic derivative
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, (2021/02/10)
The invention relates to a method for preparing a benzo oxygen-containing aliphatic heterocyclic derivative, which specifically comprises the following steps: (1) carrying out nitration reaction on acompound shown as a formula I-1 to obtain a compound shown as a formula I-2; (2) carrying out reduction reaction on the compound shown in the formula I-2 to obtain a compound shown in a formula I-3; (3) performing halogenation reaction on the compound shown in the formula I-3 to obtain a compound shown in a formula I-4; (4) carrying out diazotization reaction on the compound shown as the formula I-4, and further reacting the obtained product with a halogenated metal salt to generate a compound shown as a formula I;.
Preparation method of benzofuran derivative
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, (2020/02/06)
The invention discloses a preparation method for synthesizing a benzofuran derivative. The specific implementation method is as shown in the specification. The method has novel synthetic route, simpleand convenient operation, high yield, and good safety, and is suitable for industrial production. A novel synthetic method of an intermediate VI is also designed, a Wittig reaction is carried out, and then ring-closing is carried out to obtain a benzofuran ring.
LFA-1 INHIBITOR AND POLYMORPH THEREOF
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, (2014/02/16)
Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.