59524-69-5

Basic information

• Product Name: Boc-Ala-Gln-OBzl
• Synonyms: Boc-Ala-Gln-OBzl
• CAS NO: 59524-69-5
• Molecular Weight: 407.467
• Mol File: 59524-69-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Boc-Ala-Gln-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Ala-Gln-OBzl(59524-69-5)
• EPA Substance Registry System: Boc-Ala-Gln-OBzl(59524-69-5)

Safety Data

• Hazardous Substances Data: 59524-69-5(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 2419-53-6 Glutamine benzyl ester hydrochloride 
• 2483-49-0 tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester 
• 66449-95-4 L-glutamine benzyl ester trifluoroacetate 

Relevant articles and documents

The hydrolysis of primary amide groups in Asn/Gln-containing peptides

Peptides Boc-Ala-Asn/Gln-OH and Boc-Asn/Gln-Ala-OH were saponified with barium hydroxide to corresponding Asp/Glu-containing peptides. Under the conditions of saponification, Boc-Asn-Ala-OH additionally afforded Boc-Asp-OH, isopeptide Boc-Asp(Ala)-OH, and Boc-NHSuc > Ala-OH, with the third being the key intermediate in these transformations. Boc-Asp(OMe)-Ala-OMe underwent similar transformations under treatment with diazomethane or triethylamine. Saponification with barium hydroxide was accompanied by a high epimerization of N-terminal amino acid residues, whereas the products of the diazomethane treatment of Boc-Asp(OMe)-Ala-OMe had a low degree of epimerization.