5989-77-5

Basic information

• Product Name: DIHYDROERGOTAMINE TARTRATE CRYSTALLINE
• Synonyms: DIHYDROERGOTAMINE TARTRATE CRYSTALLINE;9,10-dihydroergotaminetartrate;dihydro-ergotamintartrate(2:1)(salt);bis[5'alpha-benzyl-9,10alpha-dihydro-12'-hydroxy-2'-methylergotaman-3',6',18-trione] [R-(R*,R*)]-tartrate;DIHYDROERGOTAMINETARTRATE[DD];Dihydroergotamintartrat
• CAS NO: 5989-77-5
• Molecular Formula: 2C33H37N5O5.C4H6O6
• Molecular Weight: 1317.46
• EINECS: 227-816-1
• Product Categories: Alkaloids;Biochemistry;Indole Alkaloids
• Mol File: 5989-77-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 205 °C (decomp)(Solv: methanol, 95% (67-56-1))
• Boiling Point: 899.5oC at 760 mmHg
• Flash Point: 497.8oC
• Appearance: /
• Vapor Pressure: 8.09E-35mmHg at 25°C
• Refractive Index: -55 ° (C=1, Pyridine)
• Solubility: Very slightly soluble in water, sparingly soluble in alcohol
• CAS DataBase Reference: DIHYDROERGOTAMINE TARTRATE CRYSTALLINE(CAS DataBase Reference)
• NIST Chemistry Reference: DIHYDROERGOTAMINE TARTRATE CRYSTALLINE(5989-77-5)
• EPA Substance Registry System: DIHYDROERGOTAMINE TARTRATE CRYSTALLINE(5989-77-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• RIDADR: 1544
• WGK Germany: 3
• RTECS: KE8000000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 5989-77-5(Hazardous Substances Data)

Usage

Description

DIHYDROERGOTAMINE TARTRATE CRYSTALLINE is a semisynthetic ergot alkaloid, which is the L-(+)-tartaric acid salt of dihydroergotamine. It is characterized by its white or almost white crystalline powder or colorless crystals. DIHYDROERGOTAMINE TARTRATE CRYSTALLINE has weaker oxytocic and vasoconstrictor properties compared to ergotamine and is known for its vascular serotonin receptor activation properties.

Uses

Used in Pharmaceutical Industry:
DIHYDROERGOTAMINE TARTRATE CRYSTALLINE is used as an antimigraine agent for the treatment of migraine and orthostatic hypotension. It functions as a serotonin antagonist, helping to alleviate the symptoms of migraines and regulate blood pressure.
Used in Oncology:
DIHYDROERGOTAMINE TARTRATE CRYSTALLINE is used as an anticancer agent, particularly inducing lung cancer cell death through apoptosis and mitophagy. Its ability to target and eliminate cancer cells makes it a valuable compound in the field of oncology.
Used in Drug Delivery Systems:
In addition to its direct applications, DIHYDROERGOTAMINE TARTRATE CRYSTALLINE can also be utilized in the development of novel drug delivery systems to enhance its efficacy and bioavailability in various medical applications.

InChI:InChI=1/C33H37N5O5.C4H6O6/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;5-1(3(7)8)2(6)4(9)10/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1-2,5-6H,(H,7,8)(H,9,10)