601-90-1

Basic information

• Product Name: 7β,15β-Dihydroxyprogesterone
• Synonyms: 7β,15β-Dihydroxyprogesterone
• CAS NO: 601-90-1
• Molecular Formula: C₂₁H₃₀O₄
• Molecular Weight: 346.4605
• Mol File: 601-90-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7β,15β-Dihydroxyprogesterone(CAS DataBase Reference)
• NIST Chemistry Reference: 7β,15β-Dihydroxyprogesterone(601-90-1)
• EPA Substance Registry System: 7β,15β-Dihydroxyprogesterone(601-90-1)

Safety Data

• Hazardous Substances Data: 601-90-1(Hazardous Substances Data)

Upstream product

• 57-83-0 Progesterone 

Relevant articles and documents

Novel metabolites of dehydroepiandrosterone and progesterone obtained in Didymosphearia igniaria KCH 6670 culture

Dehydroepiandrosterone (DHEA) (10) and its five derivatives: testosterone (1), androstenedione (2), 17α-methyltestosterone (6), progesterone (13) and pregnenolone (14) were subjected to microbial transformation by the filamentous fungus Didymosphaeria igniaria KCH 6670. The predominant metabolism of the incubated 5-ene steroids (10 and 14) occurred through 3β-hydroxy-steroid dehydrogenase/5,4-en isomerase pathways resulting in the generation of a 4-en-3-oxo system on ring-A. The transformations of C 19 steroids (1, 2, and 10) included a hydroxylation at 7α position, ketone-alcohol interconversion at C-17 and reduction of the double bond at C-4 and 3-keto group to the 3β-alcohol with 5α- stereochemistry at A/B ring. D. igniaria also carried out 6(7)-dehydrogenation and 6,7β-epoxidation during transformation of DHEA. Under these conditions transformation of DHEA (10) gave four products: 7α-hydroxyandrost-4-en-3, 17-dione (4), 17β-hydroxyandrost-4,6-dien-3-one (11), 17β- hydroxyandrost-6β-epoxy-4-en-3-one (12) and 3β,17β-dihydroxy- 5α-androstane (5). The compounds 11 and 12 are identified as DHEA metabolites for the first time. The transformation of C21 steroids (13 and 14) led to the mixture of mono- (mainly 11α- and 15β-) and dihydroxy- (7α,15β-; 14α,15β-; 11α,15β-; 11α,14α-) products. 7α,15β-Dihydroxypregnan-4-en-3,20- dione (18) and 14α,15β-dihydroxypregnan-4-en-3,20-dione (19) were found to be new compounds. The main product of transformation of 17α-methyltestosterone (6) was 12β-hydroxy-17α- methyltestosterone (7). The results of these transformations demonstrate the dependence of hydroxylation position on the structure of steroid nucleus.

Chick oviduct progesterone receptor binding of 15β,17-dihydroxyprogesterone and its analogues

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