60282-87-3 Usage
Description
Gestodene is a progestogen, a steroid hormone with a progesterone-like profile of activity. It is one of the three new gonane progestins and is the most potent on a per weight basis in regard to progestational effects. Gestodene has little or no estrogenic effect and, in in vivo animal studies, has shown less androgenic activity compared to progestins found in older combination oral contraceptive formulations. It is available under the brand name Femodene and is characterized by its white crystalline solid appearance.
Uses
Used in Pharmaceutical Industry:
Gestodene is used as an orally active gestogen with a progesterone-like profile of activity for the development of oral contraceptives. It is combined with estrogen to create a contraceptive that helps regulate the menstrual cycle and prevent pregnancy.
Used in Hormonal Regulation:
Gestodene is used as a progestogen hormonal agent to help regulate the menstrual cycle during the childbearing years. Estrogens and progestins, including gestodene, are female hormones that are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle.
Check Digit Verification of cas no
The CAS Registry Mumber 60282-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,8 and 2 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60282-87:
(7*6)+(6*0)+(5*2)+(4*8)+(3*2)+(2*8)+(1*7)=113
113 % 10 = 3
So 60282-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
60282-87-3Relevant articles and documents
A simple synthesis of gestodene from 18-methyl-4-estren-3,17-dione
Ferraboschi, Patrizia,Grisenti, Paride,Onofri, Andrea,Prestileo, Paolo
, p. 1838 - 1840 (2004)
A simple synthesis enables us to obtain the progestin, gestodene, in five steps and satisfactory yields from 18-methyl-4-estren-3,17-dione. This was accomplished through the selective protection of the C-3 carbonyl group as a cyclic ketal and the installation of a phenylsulfoxide group at the C-16 position.
Process for the preparation of gestodene
-
, (2011/09/12)
The invention relates to a process for the preparation of a compound of formula (I) : wherein R1 and R2 are as defined in the description, by reaction of a compound of formula (II) with a base. Compound (I) is an intermediate useful in the preparation of gestodene.
KIT FOR FEMALE MAMMALS, COMPRISING A COMBINATION OF GESTAGEN AND OESTROGEN
-
, (2008/06/13)
-