604-34-2 Usage
Description
Cholesteryl arachidonate, also known as a cholesterol ester, is a lipid molecule found in plasma, the adrenal gland, and associated with the neutral core of low-density lipoprotein (LDL). It plays a significant role in various physiological processes, including macrophage activation, foam cell formation in atherosclerosis, and prostaglandin synthesis in rat adrenocortical cells. The hydrolysis of cholesteryl arachidonate releases arachidonic acid, which is essential for various cellular functions.
Uses
Used in Medical Research:
Cholesteryl arachidonate is used as a biomarker for [application type] to study the differences in bronchoalveolar lavage fluid (BALF) levels in pediatric cystic fibrosis patients compared to healthy controls. [application reason] The increased levels of cholesteryl arachidonate in the BALF of cystic fibrosis patients can provide insights into the pathophysiology of the disease and potential therapeutic targets.
Used in Obstetrics and Gynecology:
Cholesteryl arachidonate is used as a diagnostic marker for [application type] to identify women with chorioamnionitis during pregnancy. [application reason] Elevated levels of cholesteryl arachidonate in placentas can indicate the presence of chorioamnionitis, which may require medical intervention to ensure the health of the mother and the baby.
Used in Cardiovascular Research:
Cholesteryl arachidonate is used as a research tool for [application type] to study the role of oxidized arachidonate moieties in macrophage activation and foam cell formation in atherosclerosis. [application reason] Understanding the mechanisms behind these processes can lead to the development of novel therapeutic strategies for the prevention and treatment of atherosclerosis.
Used in Endocrinology:
Cholesteryl arachidonate is used as a substrate for [application type] to investigate the role of hydrolysis in the release of arachidonic acid during ACTH-stimulated prostaglandin synthesis in rat adrenocortical cells. [application reason] This research can provide valuable information on the regulation of prostaglandin synthesis and its implications in adrenal gland function and overall endocrine health.
Check Digit Verification of cas no
The CAS Registry Mumber 604-34-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 604-34:
(5*6)+(4*0)+(3*4)+(2*3)+(1*4)=52
52 % 10 = 2
So 604-34-2 is a valid CAS Registry Number.
InChI:InChI=1/C47H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-27-45(48)49-40-32-34-46(5)39(36-40)28-29-41-43-31-30-42(38(4)26-24-25-37(2)3)47(43,6)35-33-44(41)46/h11-12,14-15,17-18,20-21,28,37-38,40-44H,7-10,13,16,19,22-27,29-36H2,1-6H3/b12-11+,15-14+,18-17+,21-20+/t38-,40+,41+,42-,43+,44+,46+,47-/m1/s1
604-34-2Relevant articles and documents
Enzymatic synthesis of steryl esters of polyunsaturated fatty acids
Shimada, Yuji,Hirota, Yoshinori,Baba, Takashi,Sugihara, Akio,Moriyama, Shigeru,Tominaga, Yoshio,Terai, Tadamasa
, p. 713 - 716 (2007/10/03)
Steryl esters of long-chain fatty acids have water-holding properties, and polyunsaturated fatty acids (PUFA) have various physiological functions. Because steryl ester of PUFA can be expected to have both features, we attempted to synthesize steryl esters of PUFA by enzymatic methods. Among lipases used, Pseudomonas lipase was the most effective for the synthesis of cholesteryl docosahexaenoate. When a mixture of cholesterol/docosahexaenoic acid (3:1, mol/mol), 30% water, and 3000 units/g of lipase was stirred at 40 °C for 24 h, the esterification extent attained 89.5%. Under the same reaction conditions, cholesterol, cholestanol, and sitosterol were also esterified efficiently with docosahexaenoic, eicosapentaenoic, arachidonic, and γ-linolenic acids.
