605-88-9

Basic information

• Product Name: 2-methylbenzo[h]quinoline
• Synonyms: 2-methylbenzo[h]quinoline
• CAS NO: 605-88-9
• Molecular Formula: C₁₄H₁₁N
• Molecular Weight: 193.24384
• EINECS: 210-097-3
• Mol File: 605-88-9.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 352.5°C at 760 mmHg
• Flash Point: 154.8°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 7.75E-05mmHg at 25°C
• Refractive Index: 1.703
• CAS DataBase Reference: 2-methylbenzo[h]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylbenzo[h]quinoline(605-88-9)
• EPA Substance Registry System: 2-methylbenzo[h]quinoline(605-88-9)

Safety Data

• Hazardous Substances Data: 605-88-9(Hazardous Substances Data)

Usage

General Description

2-Methylbenzo[h]quinoline is a chemical compound with a molecular formula C15H11N. It is a polycyclic aromatic hydrocarbon (PAH) containing a quinoline ring and a methyl group. 2-methylbenzo[h]quinoline is a yellow crystalline solid that is insoluble in water, but soluble in organic solvents. 2-Methylbenzo[h]quinoline is a suspected human carcinogen and has been found in cigarette smoke and combustion emissions. It has been studied for its potential role in causing DNA damage and its ability to induce mutagenic and carcinogenic effects in cells. Due to its potential health hazards, 2-methylbenzo[h]quinoline is considered an environmental pollutant and a toxic substance that requires proper handling and disposal procedures.

InChI:InChI=1/C14H11N/c1-10-6-7-12-9-8-11-4-2-3-5-13(11)14(12)15-10/h2-9H,1H3

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 134-32-7 1-amino-naphthalene 
• 123-63-7 paracetaldehyde 
• 815-68-9 3-acetylpentane-2,4-dione 
• 176853-41-1 1-amino naphthalene-2-carboxaldehyde 
• 109-92-2 ethyl vinyl ether 
• 123-73-9 crotonaldehyde 
• 1004545-92-9 1-(1-aminonaphthalen-2-yl)but-3-en-1-ol 
• 74-85-1 ethene 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 91-59-8 naphthalen-2-ylamine 
• 74-86-2 acetylene 
• 230-27-3 7,8-benzoquinoline 

Downstream Products

• 1446451-55-3 2,2'-(2-phenylpropane-1,3-diyl)bis(benzo[h]quinoline) 
• 1318193-44-0 N-(2-(benzo[h]quinolin-2-yl)-1-phenylethyl)-4-methylbenzenesulfonamide 
• 224564-90-3 (2-methyl-7,8-benzoquinolinato)hydrido(aqua)bis(triphenylphosphine)iridium(III) tetrafluoroborate 
• 904886-12-0 2-formylbenzo[h]quinoline 

Relevant articles and documents

Rhodium-Catalyzed C-H Annulation of Free Anilines with Vinylene Carbonate as a Bifunctional Synthon

Chemical transformation with vinylene carbonate as an emerging synthetic unit has recently attracted considerable attention. This report is a novel conversion pattern with vinylene carbonate, in which such a vibrant reagent unprecedentedly acts as a difunctional coupling partner to complete the C-H annulation of free anilines. From commercially available substrates, this protocol leads to the rapid construction of synthetically versatile 2-methylquinoline derivatives (43 examples) with excellent functionality tolerance.

Synthesis of benzoquinoline derivatives from formyl naphthylamines via Friedl?nder annulation under metal-free conditions

Abstract: The synthesis of benzoquinolines and benzoquinolinones via Friedl?nder-type condensation of aminonaphthalene carbaldehydes with (1) primary or secondary alcohols mediated by urea/KOH or with (2) diketones or β-ketoesters is described. The behavi

Traceless Directing-Group Strategy in the Ru-Catalyzed, Formal [3 + 3] Annulation of Anilines with Allyl Alcohols: A One-Pot, Domino Approach for the Synthesis of Quinolines

A unique, ruthenium-catalyzed, [3 + 3] annulation of anilines with allyl alcohols in the synthesis of substituted quinolines is reported. The method employs a traceless directing group strategy in the proximal C-H bond activation and represents a one-pot Domino synthesis of quinolines from anilines.