60519-03-1Relevant articles and documents
Reduction of Aldehydes with Formic acid in Ethanol using Immobilized Iridium Nanoparticles on a Triazine-phosphanimine Polymeric Organic Support
Panahi, Farhad,Haghighi, Fatemeh,Khalafi-Nezhad, Ali
, (2020/07/06)
A novel triazine-phosphanimine polymeric organic support (TPA) was synthesized successfully by a controllable one-pot method using melamine (1,3,5-triazine-2,4,6-triamine) and trichlorophosphane (PCl3). The TPA substrate is a material incorporating P and N atoms which can coordinate with metals as a pincer ligand to stabilize them, providing an efficient heterogeneous support to prepare recyclable transition metal catalyst systems. In this study, TPA was used as support to immobilize iridium nanoparticles in the range of ~8 nm on its surface, resulting in the generation of a novel iridium nanocatalyst system (INP-TPA-POP). This catalyst system was characterized using different microscopic and spectroscopic techniques such as FT-IR, TEM, XPS, XRD, SEM, EDX, elemental analysis, ICP and BET analysis. The INP-TPA-POP nanocatalyst exhibited remarkable activity in reduction of aldehydes to alcohols using formic acids as reducing agent in ethanol as solvent.
Ambient-Pressure and Base-Free Aldehyde Hydrogenation Catalyst Supported by a Bifunctional Abnormal NHC Ligand
Garhwal, Subhash,Maji, Babulal,Semwal, Shrivats,Choudhury, Joyanta
supporting information, p. 4720 - 4725 (2018/12/14)
Catalytic aldehyde hydrogenation is an essential and routinely used chemical synthesis process in both academia and industry. However, there is a serious scarcity of efficient homogeneous catalysts for this process to work under highly demanding atmospheric-pressure, base-free, and aqueous conditions. Addressing this problem, herein, we report an iridium-based catalyst for facile atmospheric-pressure and base-free hydrogenation of various aromatic, heteroaromatic, and aliphatic aldehydes. The catalyst also displays excellent chemoselectivity toward aldehyde over other carbonyl functionalities and unsaturated motifs. Moreover, the catalyst is found to work in H2O (and in H2O-ethanol) medium at ambient temperature. All of the above attributes have been possible to incorporate into this unique catalyst via employing a hybrid bifunctional ligand, which plays a crucial role in facilitating the cleavage of H2 as well as effectively delivering hydride to the substrate without any help of base or pressure.
Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin
Matthews, Jay M.,Liotta, Fina,Hageman, William,Rivero, Ralph A.,Westover, Lori,Yang, Maria,Xu, Jun,Demarest, Keith
, p. 1155 - 1159 (2007/10/03)
The use of a multiplex mimetic assay led us to identify 1,4-dihydropyrimidines with potent and selective calcitonin receptor mimetic activity. Subsequent modification of the dihydropyrimidine scaffold led to a series of molecules that were efficacious in a neonatal mouse calvaria in vitro model. Dihydropyrimidine 5h, in particular, was identified as a calcitonin mimetic (EC50=6 μM), active in-vivo in the Weanling rat model when administered subcutaneously.
