606-90-6 Usage
Originator
Piprinhydrinate ,Kraeber and Co. GmbH
Manufacturing Process
A mixture of 46 g of 1-methyl-4-piperidinol (0.4 mol), 49.4 g of benzhydryl bromide (0.2 mol) and 100 ml of xylene was refluxed for approximately 24 hours. The reaction mixture separated into two phases with the upper phase containing the desired ether compound dissolved in xylene. The lower phase consisted of the hydro bromide salt of the excess 1-methyl-4-piperidinol. The upper phase was separated from the lower phase and the desired benzhydryl ether recovered in the crude state by distilling off the xylene under reduced pressure. The crude benzhydryl ether was a clear reddish oil. It was dissolved in 75 ml of 20% hydrochloric acid and the aqueous acid solution then washed three times with 50 ml portions each of ethyl ether. The aqueous acid solution was then decolorized with activated carbon and thereafter slowly admixed with 75 ml of 28% aqueous ammonia. The benzhydryl ether separated as an oily material and was removed from the aqueous mixture by extraction with three 50 ml portions of ethylether. On evaporation of the ethyl ether from the ethyl ether solution, the benzhydryl ether was recovered as a pale yellow oil. The benzhydryl ether was dissolved in 60 ml of isopropanol and the isopropanol solution acidified to a PH of 3 with dry hydrogen chloridemethanol solution. The acidic propanol solution was then diluted with ethyl ether until a faint turbidity was observed. In a short time, the crystalline hydrochloride salt of the benzhydryl ether separated from the propanol solution. The crystallized salt was recrystallized once from 75 ml of isopropanol with the aid of ethyl ether in order to further purify the material. A yield 24.5 g of the pure hydrochloride salt 1-methylpiperldyl-4-benzhydryl ether (diphenylpyraline) was obtained. This was 39% of the theoretical yield. The pure material had a melting point of 206°C.107 g (0.5 mole) 8-chlorotheophylline was dissolved in the diluted solution of ammonia contained 0.5 moles NH3. 1 equivalent of this ammonim salt was mixed with 1 equivalent hydrochloride of 1-methylpiperldyl-4-benzhydryl ether in 150 ml of water. 4-Diphenylmethoxy-1-methylpiperidine compound of 8chlorotheophylline precipitated, filtered off, washed, dried. Yield was quantitative. MP: 151-152°C.
Therapeutic Function
Antihistaminic, Antiemetic
Check Digit Verification of cas no
The CAS Registry Mumber 606-90-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 606-90:
(5*6)+(4*0)+(3*6)+(2*9)+(1*0)=66
66 % 10 = 6
So 606-90-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO.C7H7ClN4O2/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h2-11,18-19H,12-15H2,1H3;1-2H3,(H,9,10)
