606144-05-2

Basic information

• Product Name: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]iMidazole-6-carboxaMide
• Synonyms: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]iMidazole-6-carboxaMide;5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6;1H-BenziMidazole-6-carboxaMide,5-[(4-broMo-2-chlorophenyl)aMino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-Methyl-;6-(4-bromo-2-chloroanilino)-N-(2-ethenoxyethoxy)-7-fluoro-3-methylbenzimidazole-5-carboxamide;CDS-5015;5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazol;5-[(4-Bromo-2-chlorophenyl)amino]-N-[2-(ethenyloxy)ethoxy]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxamide
• CAS NO: 606144-05-2
• Molecular Formula: C19H17BrClFN4O3
• Molecular Weight: 483.7186832
• Mol File: 606144-05-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• PKA: 2.93±0.10(Predicted)
• CAS DataBase Reference: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]iMidazole-6-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]iMidazole-6-carboxaMide(606144-05-2)
• EPA Substance Registry System: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]iMidazole-6-carboxaMide(606144-05-2)

Safety Data

• Hazardous Substances Data: 606144-05-2(Hazardous Substances Data)

Usage

General Description

The chemical compound 5-(4-bromo-2-chlorophenylamino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]iMidazole-6-carboxamide is a complex molecule with multiple functional groups. It contains a benzimidazole core structure with a substituted amine, fluoro, bromo, and chloro groups attached to the benzene ring. Additionally, it has a methyl and carboxamide group attached to the benzimidazole core. The compound also features an ethoxy and vinyloxy group linked to the nitrogen at position 1 of the benzimidazole ring. This chemical structure suggests potential pharmaceutical applications, as benzimidazole derivatives have been investigated for their various pharmacological activities, such as antimicrobial, antiviral, antitumor, and anti-inflammatory properties.

Upstream product

• 1000340-06-6 methyl 5-[(4-bromophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate 
• 606144-02-9 methyl 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate 
• 606093-58-7 4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester 
• 391212-29-6 O-(2-vinyloxyethyl)hydroxylamine 
• 606144-04-1 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid 

Relevant articles and documents

INTERMEDIATES OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MAP2K OR MEK) INHIBITORS AND PROCESS FOR THEIR PREPARATION

The present invention relates to intermediates of Mitogen-activated protein kinase kinase (MAP2K or MEK) inhibitors such as Selumetinib, Binimetinib and process for their preparation. The present invention also relates to process for the 5 preparation of MEK inhibitors such as Selumetinib, and Binimetinib.

N3 alkylated benzimidazole derivatives as MEK inhibitors

Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.