607-31-8

Basic information

• Product Name: 4-Methoxyquinoline
• Synonyms: 4-Methoxyquinoline
• CAS NO: 607-31-8
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• EINECS: -0
• Product Categories: pharmacetical
• Mol File: 607-31-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 41°C
• Boiling Point: 284.68°C (rough estimate)
• Flash Point: 89.7 °C
• Appearance: /
• Density: 1.1202 (rough estimate)
• Vapor Pressure: 0.0444mmHg at 25°C
• Refractive Index: 1.6070 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 6.37±0.13(Predicted)
• CAS DataBase Reference: 4-Methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxyquinoline(607-31-8)
• EPA Substance Registry System: 4-Methoxyquinoline(607-31-8)

Safety Data

• Hazardous Substances Data: 607-31-8(Hazardous Substances Data)

Usage

Description

4-Methoxyquinoline is an organic compound characterized by the presence of a methoxy group attached to the 4-position of the quinoline ring. It is known for its unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
4-Methoxyquinoline is used as a reactant in the synthesis of hybrid quinoline-4-yloxadiazoles/oxathiadiazoles, which are potent antifungal agents. These agents are valuable in the development of new drugs to combat fungal infections, offering an alternative to conventional antifungal treatments.

InChI:InChI=1/C10H9NO/c1-12-10-6-7-11-9-5-3-2-4-8(9)10/h2-7H,1H3

Upstream product

• 67-56-1 methanol 
• 611-35-8 4-chloroquinoline 
• 124-41-4 sodium methylate 
• 186581-53-3 diazomethane 
• 529-37-3 4(1H)-quinolinone 
• 611-36-9 quinolin-4-ol 
• 856089-56-0 N-(p-toluenesulfonyl)-4-chloro-1,2-dihydroquinoline 
• 15733-83-2 4-methoxyquinoline-2-carboxylic acid 
• 74-88-4 methyl iodide 
• 865-33-8 potassium methanolate 
• 3964-04-3 4-bromoquinoline 
• 86-98-6 4,7-dichloroquinoline 
• 26707-52-8 7-chloro-4-methoxyquinoline 
• 65148-06-3 N-((4-methylphenyl)sulfonyl)-N-phenyl-beta-alanine 

Downstream Products

• 14547-98-9 4-methoxyquinoline-N-oxide 
• 681827-50-9 benzyl 2-methyl-4-oxo-3,4-dihydroquinoline-1(2H)-carboxylate 
• 15793-93-8 4-hydrazineylquinoline 

Relevant articles and documents

Structure and synthesis of echinorin, an alkaloid from Echinops ritro L. and sphaerocephalus L. (Asteraceae)

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PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

General and Practical Potassium Methoxide/Disilane-Mediated Dehalogenative Deuteration of (Hetero)Arylhalides

Herein we describe a general, mild and scalable method for deuterium incorporation by potassium methoxide/hexamethyldisilane-mediated dehalogenation of arylhalides. With CD3CN as a deuterium source, a wide array of heteroarenes prevalent in pharmaceuticals and bearing diverse functional groups are labeled with excellent deuterium incorporation (>60 examples). The ipso-selectivity of this method provides precise access to libraries of deuterated indoles and quinolines. The synthetic utility of our method has been demonstrated by the incorporation of deuterium into complex natural and drug-like compounds.