609-21-2 Usage
Chemical Properties
beige to pale brown crystalline powder
Synthesis
The synthesis of 4-amino-2,6-dibromophenol is as follows:4-Nitro-2,6-dibromophenol (2.97g, 10mmol) was dissolved in ethanol (15ml) and water (3ml), and acetic acid (1ml) was added. Then heat and stir to raise the temperature to 80°C, and add iron powder (1.68g, 30mmol) in batches. After the addition is complete, the reaction solution is kept warm for 30 minutes, heating is stopped, filtered while hot, the filtrate is concentrated under reduced pressure, then ethyl acetate and water are added to the concentrated residue to extract, the organic phases are combined and dried, filtered, and the solvent is removed under reduced pressure. The residue was finally separated by column chromatography (ethyl acetate/petroleum ether=1/3) to obtain 4-amino-2,6-dibromophenol (2.52g, 94.4% yield).
Check Digit Verification of cas no
The CAS Registry Mumber 609-21-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 609-21:
(5*6)+(4*0)+(3*9)+(2*2)+(1*1)=62
62 % 10 = 2
So 609-21-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H5Br2NO/c7-4-1-3(9)2-5(8)6(4)10/h1-2,10H,9H2
609-21-2Relevant articles and documents
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Meyer,H.
, p. 263 (1900)
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Pyridazinone derivative and application thereof
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Paragraph 0298-0303, (2020/11/23)
The invention provides a pyridazinone derivative and an application thereof, the pyridazinone derivative with the structure shown in the formula (I) provided by the invention has good activity as a thyroid hormone beta receptor agonist by selecting a specific modification group. The compound can be used for treating and/or preventing diseases caused by thyroid hormone regulation.
Synthesis and some transformations of polybrominated quinone diazides
Vasin,Fadin,Tarasova
, p. 1815 - 1821 (2018/02/06)
The reduction of polybrominated o- and p-nitrophenols with granular tin in concentrated aqueous HCl gave polybrominated aminophenols which were diazotized with sodium nitrite in concentrated sulfuric acid at 0°C to obtain polybrominated o- and p-quinone diazides. Their thermolysis with elimination of nitrogen generated ketocarbenes which reacted with acetylacetone to form insertion products at the activated methylene group. Ketocarbenes generated from o-quinone diazides reacted with typical dipolarophiles such as acetonitrile, benzonitrile, styrene, and phenylacetylene to afford the corresponding [3 + 2]-cycloaddition products.
