611-91-6

Basic information

• Product Name: 2,3-DIBROMO-3-PHENYLPROPIOPHENONE
• Synonyms: 2,3-dibromo-1,3-diphenyl-1-propanon;LABOTEST-BB LT00064506;BENZALACETOPHENONE DIBROMIDE;CHALCONE DIBROMIDE;DIBROMOCHALCONE;2,3-DIBROMO-3-PHENYLPROPIOPHENONE;2,3-DIBROMO-1,3-DIPHENYL-1-PROPANONE;2,3-DIBROMO-1,3-DIPHENYLPROPAN-1-ONE
• CAS NO: 611-91-6
• Molecular Formula: C₁₅H₁₂Br₂O
• Molecular Weight: 368.06
• EINECS: 210-282-9
• Mol File: 611-91-6.mol
• Article Data: 61

Chemical Properties

• Melting Point: 156 °C
• Boiling Point: 411.5°C at 760 mmHg
• Flash Point: 104.7°C
• Appearance: /
• Density: 1.631g/cm³
• Vapor Pressure: 5.57E-07mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 2,3-DIBROMO-3-PHENYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIBROMO-3-PHENYLPROPIOPHENONE(611-91-6)
• EPA Substance Registry System: 2,3-DIBROMO-3-PHENYLPROPIOPHENONE(611-91-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 611-91-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-white crystalline powder

InChI:InChI=1/C15H12Br2O/c16-13(11-7-3-1-4-8-11)14(17)15(18)12-9-5-2-6-10-12/h1-10,13-14H/t13-,14-/m1/s1

Upstream product

• 6935-75-7 2-bromo-1,3-diphenyl-2-propen-1-one 
• 100-52-7 benzaldehyde 
• 70-11-1 α-bromoacetophenone 
• 60-29-7 diethyl ether 
• 78500-93-3 benzyldimethyl(phenacyl)ammonium bromide 
• 591-51-5 phenyllithium 
• 94-41-7 benzalacetophenone 
• 10035-10-6 hydrogen bromide 
• 64-19-7 acetic acid 
• 408339-45-7 3-ethoxy-2-bromo-1,3-diphenyl-propan-1-one 
• 51012-66-9 2-benzyl-2-bromoacetophenone 
• 1083-30-3 dihydrochalcone 
• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 614-47-1 1,3-diphenyl-propen-3-one 

Downstream Products

• 6281-88-5 1,3-diphenyl-2,3-dipiperidino-propan-1-one 
• 6935-75-7 2-bromo-1,3-diphenyl-2-propen-1-one 
• 2211-61-2 ((2S,3S)-1-Cyclohexyl-3-phenyl-aziridin-2-yl)-phenyl-methanone 
• 2211-61-2 trans-1-cyclohexyl-2-phenyl-3-benzoylaziridine 
• 69435-95-6 (1-methyl-3-phenyl-aziridin-2-yl)-phenyl-methanone 
• 66636-77-9 1,3-diphenyl-3-[1,2,4]triazol-1-yl-propenone 
• 113854-33-4 5-methyl-2,4,7-triphenylpyrazolo<4,5-b>pyridine 
• 13591-60-1 endo-2,4,6-triphenyl-1,3-diazabicyclo<3.1.0>hex-3-ene 
• 13591-60-1 exo-2,4,6-triphenyl-1,3-diazabicyclo<3.1.0>hex-3-ene 
• 117836-54-1 5-Chloro-1,2-diphenyl-1,1a-dihydro-3,7b-diaza-cyclopropa[a]naphthalene 
• 18039-32-2 1,1a-dihydro-1,2-diphenylazirino<1,2-a>quinoxaline 
• 87275-58-9 1,3-diphenyl-4-benzoyl-5-phenylimidazolidin-2-one 
• 50515-45-2 β-methoxy-chalcone 
• 73638-84-3 1,3-diphenyl-3-[1,2,4]triazol-1-yl-propenone 

Relevant articles and documents

Do C-H...O and C-H...π interactions help to stabilize a non-centrosymmetric structure for racemic 2,3-dibromo-1,3-diphenyl-propan-1-one?

The racemic title compound, C15H12Br2O, crystallizes in a non-centrosymmetric structure and displays a significant non-linear optical response to red light. The crystal packing is influenced by C-H...O and C-H...π interactions. One of the former bonds has a short H...O separation of 2.27 A.

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.

Visible light-mediated metal-free double bond deuteration of substituted phenylalkenes

Various bromophenylalkenes were reductively photodebrominated by using 1,3-dimethyl-2-phenyl-1H-benzo-[d]imidazoline (DMBI) and 9,10-dicyanoanthracene. With deuterated DMBI analogs (the most effective was DMBI-d11), satisfactory to excellent isotopic yields were obtained. DMBI-d11 could also be regenerated from the reaction mixtures with a recovery rate of up to 50%. The combination of the photodebromination reaction with conventional methods for bromoalkene synthesis enables sequential monodeuteration of a double bond without the necessity of a metal catalyst. This journal is