61315-87-5

Basic information

• Product Name: Benzaldehyde, 3-hydroxy-4-propoxy-
• Synonyms: Benzaldehyde,3-hydroxy-4-propoxy;3-hydroxy-4-propoxy-benzaldehyde;3-Hydroxy-4-propoxy-benzaldehyd;3-hydroxy-4-n-propoxy-benzaldehyde
• CAS NO: 61315-87-5
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 61315-87-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 3-hydroxy-4-propoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3-hydroxy-4-propoxy-(61315-87-5)
• EPA Substance Registry System: Benzaldehyde, 3-hydroxy-4-propoxy-(61315-87-5)

Safety Data

• Hazardous Substances Data: 61315-87-5(Hazardous Substances Data)

Upstream product

• 106-94-5 propyl bromide 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 71-23-8 propan-1-ol 
• 100-50-5 3-Cyclohexene-1-carboxaldehyde 
• 6314-88-1 1,2,5,6-tetrahydrobenzaldehyde diethyl acetal 

Downstream Products

• 61497-72-1 3-(benzyloxy)-4-propoxybenzaldehyde 
• 943749-68-6 3-hydroxy-4-propoxybenzaldehyde O-methyloxime 
• 76799-46-7 2,3',6-tris(benzyloxy)-4-<1-(carbo-tert-butoxy)-3,4-epoxybutoxy>-4'-propoxychalcone 
• 76799-40-1 2,3',6-tris(benzyloxy)-4-hydroxy-4'-propoxychalcone 
• 76820-14-9 2,3',6-trihydroxy-4-<1-(carbo-tert-butoxy)-3,4-dihydroxybutoxy>-4'-propoxydihydrochalcone 
• 76820-13-8 2,3',6-trihydroxy-4-(1,3-dicarbomethoxypropoxy)-4'-propoxydihydrochalcone 
• 76799-23-0 2,3'-dihydroxy-4-(carboxymethoxy)-4'-propoxy-6-(benzyloxy)chalcone 
• 99856-22-1 5-(trans-2-Nitro-vinyl)-2-propoxy-phenol 

Relevant articles and documents

Coenzyme A-Conjugated Cinnamic Acids – Enzymatic Synthesis of a CoA-Ester Library and Application in Biocatalytic Cascades to Vanillin Derivatives

We present a bioorthogonal method for the ligation of coenzyme A (CoA) with cinnamic acids. The reaction, which is the initial step in the biosynthesis of a multitude of bioactive secondary metabolites, is catalyzed by a promiscuous plant ligase and yields CoA conjugates with different functionalization in high purity and without formation of by-products. Its applicability in biosynthetic cascades is shown for the direct transformation of cinnamic acids into natural benzaldehydes (like vanillin) or artificial derivatives (e. g. ethylvanillin). (Figure presented.).

A 3, 4 - epoxy-cyclohexane METHYLAL glycol and its synthesis and use

The invention discloses a 3,4-epoxy cyclohexyl methylal diol and a synthesis method thereof. The 3,4-epoxy cyclohexyl methylal diol can be used for synthesizing multiple vanillins and isovanillins. Compared with the existing synthesis process, the synthesis method disclosed by the invention has the advantages of simple steps and low discharge amount of three wastes.

Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4

The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)aminometh-ylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here represents a novel class of potential antitumor agents, which potently and selectively inhibit CDK4 over CDK2 and CDK1. In the benzylamino headpiece, a 3-OH substituent is required on the phenyl ring for CDK4 inhibitory activity, which is further enhanced when an iodo, aryl, heteroaryl, t-butyl, or cyclopentyl substituent is introduced at the C-6 position of the isoquinoline-1,3-dione core. To circumvent the metabolic liability associated with the phenolic OH group on the 4-substituted 3-OH phenyl headpiece, we take two approaches: first, introduce a nitrogen o- or p- to the 3-OH group in the phenyl ring; second, replace the phenyl headpiece with N-substituted 2-pyridones. We present here the synthesis, SAR data, metabolic stability data, and a CDK4 mimic model that explains the binding, potency, and selectivity of our CDK4 selective inhibitors.