61448-83-7Relevant articles and documents
Antimalarial activity of 2,6-dibenzylidenecyclohexanone derivatives
Eagon, Scott,Hammill, Jared T.,Fitzsimmons, Kasey,Sienko, Natalie,Nguyen, Brandon,Law, Jarvis,Manjunath, Aashrita,Wilkinson, Steven P.,Thompson, Kara,Glidden, Julia Elizabeth,Rice, Amy L.,Falade, Mofolusho O.,Kimball, Joshua J.,DiBernardo, Celine,Guy, R. Kiplin
, (2021/07/06)
Malaria remains one of the deadliest infectious diseases worldwide and continues to infect hundreds of millions of individuals each year. Here we report the discovery and derivatization of a series of 2,6-dibenzylidenecyclohexanones targeting the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. While the initial lead compound displayed significant toxicity in a human cell proliferation assay, we were able to identify a derivative with no detectable toxicity and sub-micromolar potency.
Substituted pyrano[4,3-c]pyrazoles, compositions containing same, and method of use
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, (2008/06/13)
2,4,6,7-Tetrahydropyrano[4,3-c]pyrazoles are provided having the formula STR1 wherein Z is O, S, SO or SO2 ; R is H, halo, lower alkyl, lower alkoxy, lower alkanoyl, aroyl, cyano or CF3 ; and R' is H, lower alkyl, aryl-lower alkyl, a