61585-29-3 Usage
Description
Impurity A of Calcifediol, also known as 24,25-dihydroxyvitamin D3, is an organic chemical compound that may be present as a potential impurity in the pharmaceutical substance calcifediol. It is a key focus in ensuring the purity and quality of calcifediol products for medical and therapeutic use.
Uses
Used in Pharmaceutical Manufacturing:
Impurity A of Calcifediol is used as a regulatory and monitoring target in pharmaceutical manufacturing processes. It is subject to guidelines and specifications established by regulatory authorities such as the United States Pharmacopeia (USP) and the European Pharmacopoeia for the allowable levels of impurities in pharmaceutical substances, including calcifediol. This helps ensure the safety, efficacy, and quality of calcifediol products for medical and therapeutic use.
Check Digit Verification of cas no
The CAS Registry Mumber 61585-29-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,5,8 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 61585-29:
(7*6)+(6*1)+(5*5)+(4*8)+(3*5)+(2*2)+(1*9)=133
133 % 10 = 3
So 61585-29-3 is a valid CAS Registry Number.
61585-29-3Relevant articles and documents
NOVEL METHOD FOR SYNTHESIZING 25-OH CHOLESTEROL/CALCIFEDIOL FROM PHYTOSTEROL
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, (2020/11/23)
The present invention discloses novel method for synthesizing vegan 25-OH cholesterol/Calcifediol from inexpensive crude phytosterol. According to the method, Phytosterols are reacted to form corresponding i-steroid through tosylation and methanolysis. i-steroid on reductive ozonolysis to C-22 alcohol and conversion via C-22 tosylate to C-22 iodide in good yield. Coupling of C-22 tosylate with Grignard reagent of 4-bromo-2-methyl-2-[(trimethylsilyl)oxy] butane followed by deprotection yielded 25-OH cholesterol. In a process variant, nickel mediated conjugate addition of C-22 iodide to an electron deficient alkene ethyl acrylate and treating corresponding ester with methyl magnesium bromide as means of installing the side chain of 25-OH cholesterol in high yield. Further bromination reaction of 25-OH cholesterol diacetate followed by dehydrobromination using TBAF yielded 25-OH 7-dehydrocholesterol. Further photo reaction of 25-OH 7-dehydrocholesterol in to previtamin D3 using high or medium pressure mercury lamp and subsequent thermal reaction of previtamin D3 to 25-OH vitamin D3(Calcifediol) in good yield.