61751-42-6

Basic information

• Product Name: Benzenepropanamide, N-methyl-N-(phenylmethyl)-
• CAS NO: 61751-42-6
• Molecular Formula: C17H19NO
• Molecular Weight: 253.344
• Mol File: 61751-42-6.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: Benzenepropanamide, N-methyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamide, N-methyl-N-(phenylmethyl)-(61751-42-6)
• EPA Substance Registry System: Benzenepropanamide, N-methyl-N-(phenylmethyl)-(61751-42-6)

Safety Data

• Hazardous Substances Data: 61751-42-6(Hazardous Substances Data)

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 645-45-4 hydrocinnamic acid chloride 
• 501-52-0 3-Phenylpropionic acid 
• 433216-34-3 2-(benzyl-methyl-amino)-4-phenyl-butyronitrile 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 17105-71-4 N-methyl-N-benzylformamide 
• 38282-01-8 N-[(E)-3-phenyl-2-propenyl]diethylamine 
• 201230-82-2 carbon monoxide 
• 34420-17-2 (2-phenylethyl)boronic acid 
• 104-53-0 3-phenyl-propionaldehyde 
• 104-54-1 3-Phenylpropenol 
• 122-97-4 3-Phenyl-1-propanol 
• 23522-67-0 1,1,1,3,3,3-hexafluoropropan-2-yl 3-phenylpropanoate 
• 1002752-21-7 C₁₅H₂₃NO 

Downstream Products

• 940-43-2 N-methyl-3-phenylpropanamide 
• 100-52-7 benzaldehyde 
• 2550-26-7 4-Phenyl-2-butanone 
• 21924-11-8 1-(3-phenylpropanoyl)piperidine 
• 1002752-21-7 C₁₅H₂₃NO 
• 17077-46-2 4-(3-phenyl-propionyl)-morpholine 
• 122-97-4 3-Phenyl-1-propanol 
• 27376-57-4 N-benzyl-N-methyl-3-phenylpropan-1-amine 

Relevant articles and documents

A Hydroperoxide-Mediated Decarboxylation of α-Ketoacids Enables the Chemoselective Acylation of Amines

Strategies for the formation of amide bonds, that is, one of the most basic and important transformations in organic synthesis, have so far focused predominantly on dehydration reactions. Herein, we report and demonstrate the practical utility of a novel decarboxylative amidation of α-ketoacids by using inexpensive tert-butyl hydroperoxide (TBHP), which is characterized by high yields, a broad substrate scope, mild reaction conditions, and a unique chemoselectivity. These features enable the synthesis of peptides from amino acid derived α-ketoacids under preservation of the stereochemical information.

Amidation reaction of carboxylic acid with formamide derivative using SO3?pyridine

The amidation reaction of carboxylic acid derivatives was developed using sulfur trioxide pyridine complex (SO3?py) as a commercially available and easily handled oxidant. This method could be applied to the reaction of various aromatic and aliphatic carboxylic acids, including optically active ones, with formamide derivatives to afford the corresponding amides in good to high yields.

Dioxygen-promoted Pd-catalyzed aminocarbonylation of organoboronic acids with amines and CO: A direct approach to tertiary amides

A direct approach from organoboronic acids and amines to tertiary amides via Pd-catalyzed aerobic aminocarbonylation has been developed. The presence of O2 significantly promotes the efficiency of this transformation. This method uses commercially available organoboronic acids and cheap CO and O2 (1 atm), which renders amides an easy synthesis with broad substrate scope and high functional group tolerance.