618-57-5

Basic information

• Product Name: 2-PROPYL SUCCINIC ACID
• Synonyms: 2-Propylbutanedioic acid;PROPYLSUCCINIC ACID;2-PROPYL SUCCINIC ACID;1,2-Pentanedicarboxylic acid
• CAS NO: 618-57-5
• Molecular Formula: C7H12O4
• Molecular Weight: 160.17
• Mol File: 618-57-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 100.5 °C
• Boiling Point: 265.8±13.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 4.56±0.19(Predicted)
• CAS DataBase Reference: 2-PROPYL SUCCINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPYL SUCCINIC ACID(618-57-5)
• EPA Substance Registry System: 2-PROPYL SUCCINIC ACID(618-57-5)

Safety Data

• Hazardous Substances Data: 618-57-5(Hazardous Substances Data)

Usage

Description

2-Propylsuccinic Acid, a metabolite of valproic acid, is an organic compound that plays a significant role in the metabolism of this anticonvulsant drug. It is characterized by its unique chemical structure, which contributes to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
2-Propylsuccinic Acid is used as a key metabolite in the metabolism of valproic acid, an anticonvulsant medication. It is utilized for its mood-stabilizing properties, particularly for individuals with bipolar disorder. The presence of 2-Propylsuccinic Acid in the metabolic pathway of valproic acid highlights its importance in the therapeutic effects of the drug.
Additionally, the study of 2-Propylsuccinic Acid and its role in the metabolism of valproic acid can provide insights into the development of new drugs and therapies for neurological disorders. Understanding the metabolic pathways and the effects of 2-Propylsuccinic Acid can contribute to the advancement of pharmaceutical research and the improvement of treatment options for patients.

Upstream product

• 59322-89-3 2-cyano-3-propyl-succinic acid diethyl ester 
• 78423-27-5 1,1,2-pentanetricarboxylic acid triethyl ester 
• 89941-66-2 2-<2-Oxo-aethyl>-pentansaeure 
• 4416-99-3 1-Propyl-2-nitro-3.3-dicarbomethoxy-cyclopropan 
• 3601-52-3 opt. inakt. 4-Ethoxy-4-hydroxy-2-propyl-buttersaeure-lacton 
• 109-52-4 valeric acid 
• 615-83-8 2-bromo-pentanoic acid ethyl ester 
• 1540-28-9 ethyl 2-propylacetoacetate 
• 5699-72-9 1-Cyanobutanol 
• 139474-72-9 dimethyl (E)-2-(propylidene)succinate 
• 23143-72-8 dimethyl 2-propylsuccinate 
• 7647-01-0 hydrogenchloride 
• 51939-77-6 2,3-dicyano-hexanoic acid ethyl ester 
• 5469-28-3 n-propylfumaric acid 

Downstream Products

• 3975-88-0 D(+)-n-Propylbernsteinsaeure 
• 1518-75-8 3-n-propylthiophene 

Relevant articles and documents

Nitroalkanes and dimethyl maleate as source of 3-alkyl succinic anhydrides and (E)-3-alkylidene succinic anhydrides

Nitroalkanes react with dimethyl maleate giving a tandem Michael addition/elimination of nitrous acid. The obtained (E)-2-alkylidene dimethyl succinates are: (i) reduced to the corresponding 2-alkyl dimethyl succinates which after hydrolysis produce 1,4-dicarboxylic acids that are prone to convert into the corresponding 3-alkyl succinic anhydrides or (ii) hydrolysed to (E)-2-alkylidene-succinic acids that are easily cyclised to (E)-3-alkylidene succinic anhydrides.