61873-93-6

Basic information

• Product Name: Methyl (4-Hydroxy-3-nitrophenyl)acetate
• Synonyms: methyl (4-hydroxy-3-nitrophenyl)acetate;Methyl (4-hydroxy-3-nitrophenyl)acetate 95%;4-(2-Methoxy-2-oxoethyl)-2-nitrophenol;4-(2-Methoxy-2-oxoethyl)-2-nitrophenol, 2-Hydroxy-5-(2-methoxy-2-oxoethyl)nitrobenzene;Methyl(4-hydroxy-3-nitrophenyl)acetate95%;3-Nitro-4-hydroxyphenylacetic acid methyl ester;Methyl 3-nitro-4-hydroxyphenylacetate;4-Hydroxy-3-nitro-phenylacetic acid methl ester
• CAS NO: 61873-93-6
• Molecular Formula: C₉H₉NO₅
• Molecular Weight: 211.17
• Mol File: 61873-93-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 65-67°
• Boiling Point: 327.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.384±0.06 g/cm3(Predicted)
• PKA: 6.81±0.14(Predicted)
• CAS DataBase Reference: Methyl (4-Hydroxy-3-nitrophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (4-Hydroxy-3-nitrophenyl)acetate(61873-93-6)
• EPA Substance Registry System: Methyl (4-Hydroxy-3-nitrophenyl)acetate(61873-93-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61873-93-6(Hazardous Substances Data)

Usage

General Description

Methyl (4-Hydroxy-3-nitrophenyl)acetate, also known as p-nitrophenyl methylacetate, is a chemical compound used in various industries, including pharmaceuticals and organic synthesis. It is a colorless to pale yellow liquid with a fruity odor and is soluble in most organic solvents. It is commonly used as a reagent in the synthesis of various organic compounds and as an intermediate in the production of drugs and other fine chemicals. Methyl (4-Hydroxy-3-nitrophenyl)acetate is known for its ability to undergo nucleophilic substitution reactions and is a versatile intermediate with a wide range of applications in the chemical and pharmaceutical industries.

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 34837-88-2 methyl 2-(4-methoxy-3-nitrophenyl)acetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 156-38-7 4-hydroxyphenylacetate 
• 10463-20-4 4-hydroxy-3-nitrophenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 

Downstream Products

• 78587-72-1 methyl (3-amino-4-hydroxyphenyl)acetate 
• 185802-57-7 [4-(3-Bromo-propoxy)-3-nitro-phenyl]-acetic acid methyl ester 
• 695187-70-3 2-(4-bromophenyl)benzoxazol-5-ylacetic acid methyl ester 
• 695187-49-6 methyl 2-(2-(4-aminophenyl)benzo[d]oxazol-5-yl)acetate 
• 695187-48-5 methyl 2-(4-nitrophenyl)benzoxazole-5-acetate 
• 695187-97-4 2-(2-fluoro-4-bromophenyl)benzoxazol-5-ylacetic acid methyl ester 
• 695186-49-3 2-[(2-chloro-4-amino)phenyl]-5-benzoxazoleacetic acid methyl ester 
• 695186-53-9 methyl 2-(2-(4-amino-3-fluorophenyl)benzo[d]oxazol-5-yl)acetate 
• 695186-54-0 methyl [2-(3-fluoro-4-nitrophenyl)benzooxazol-5-yl] acetate 
• 695186-48-2 2-[(2-chloro-4-nitro)phenyl]-5-benzoxazoleacetic acid methyl ester 
• 695187-47-4 4-hydroxy-3-(4-nitrobenzoylamino)phenylacetic acid methyl ester 
• 695187-74-7 trans 2-[3-[4-[(5-methoxycarbonylmethyl)benzoxazol-2-yl]phenyl]]propenoic acid 
• 695187-44-1 3-[[(2-chloro-4-nitro)benzoyl]amino]-4-hydroxy-phenylacetic acid methyl ester 
• 695186-52-8 methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate 

Relevant articles and documents

SECONDARY METABOLITES OF Pyricularia oryzae. I. o-NITROPHENOL DERIVATIVES

o-Nitrophenol derivatives have been isolated from the culture liquid of the deuteromycete Pyricularia oryzae Cav.: 4-hydroxy-3-nitrophenylacetic acid, 4-hydroxy-3-nitrobenzyl alcohol, 1- and 2-(4-hydroxy-3-nitrophenyl)ethanols, N-(4-hydroxy-3-nitrophenylethyl)acetamide, and pyriculamide.This is the first time that any of these compounds has been isolated from natural sources.The o-nitrophenols obtained possess moderate growth-inhibiting activity in relation to rice shoots.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions (formula (I)).