619-78-3

Basic information

• Product Name: Benzene, 1-(dichloromethyl)-4-nitro-
• CAS NO: 619-78-3
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• Mol File: 619-78-3.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(dichloromethyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(dichloromethyl)-4-nitro-(619-78-3)
• EPA Substance Registry System: Benzene, 1-(dichloromethyl)-4-nitro-(619-78-3)

Safety Data

• Hazardous Substances Data: 619-78-3(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 67-64-1 acetone 
• 39184-67-3 3-chloro-3-(p-nitrophenyl)diazirine 
• 141-78-6 ethyl acetate 
• 623-91-6 diethyl Fumarate 
• 67-66-3 chloroform 
• 98-95-3 nitrobenzene 
• 111-90-0 ethoxyethoxyethanol 
• 98-87-3 benzylidene dichloride 
• 99-99-0 1-methyl-4-nitrobenzene 
• 14856-73-6 4-nitrobenzyl trimethylsilyl ether 
• 18483-99-3 2-(4-nitrobenzyloxy)tetrahydro-2H-pyran 
• 75-09-2 dichloromethane 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 55605-31-7 1-Chloro-2-methyl-2-nitro-(1-p-nitrophenyl)propan 
• 736-31-2 trans-4,4'-dinitrostilbene 
• 3284-64-8 1-nitro-4-(trichloromethyl)benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 29848-57-5 4-(difluoromethyl)nitrobenzene 
• 10542-73-1 α,α-dichloro-α-bromo-p-nitrotoluene 
• 402-54-0 p-nitrobenzotrifluoride 
• 83966-41-0 C₇H₅ClNO₂ 

Relevant articles and documents

One-pot, oxidative and selective conversion of benzylic silyl and tetrahydropyranyl ethers to gem-dichlorides using trichloroisocyanuric acid and triphenylphosphine as an efficient and neutral system

A one-pot and oxidative method is described for the first time for the conversion of benzylic trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers to gem-dichlorides using trichloroisocyanuric acid (TCCA) and triphenylphosphine (PPh3) in neutral media. Various theses substrates containing electron withdrawing or donating groups can be efficiently converted to their corresponding gem-dichlorides in good to excellent yields. The present method shows a high degree of chemoselectivity, and due to its one-pot nature is in accordance with green chemistry.

Vicarious Nucleophilic Chloromethylation of Nitroaromatics

Nitroaromatics substituted with electron-acceptor or electron-donor groups undergo vicarious nucleophilic substitution with the lithium salt of dichloromethane to provide chloromethyl-substituted nitroaromatics in good to high yields. The methodology represents a new strategy for the synthesis of benzyl chlorides.

Visible Light-Induced Oxidative Chlorination of Alkyl sp3 C-H Bonds with NaCl/Oxone at Room Temperature

A visible light-induced monochlorination of cyclohexane with sodium chloride (5:1) has been successfully accomplished to afford chlorocyclohexane in excellent yield by using Oxone as the oxidant in H2O/CF3CH2OH at room temperature. Other secondary and primary alkyl sp3 C-H bonds of cycloalkanes and functional branch/linear alkanes can also be chlorinated, respectively, under similar conditions. The selection of a suitable organic solvent is crucial in these efficient radical chlorinations of alkanes in two-phase solutions. It is studied further by the achievement of high chemoselectivity in the chlorination of the benzyl sp3 C-H bond or the aryl sp2 C-H bond of toluene.