61915-17-1

Basic information

• Product Name: (20R,22RS)-3β-Acetoxy-14-hydroxy-22-tosyloxymethyl-5β,14β-cardanolid
• CAS NO: 61915-17-1
• Molecular Weight: 602.789
• Mol File: 61915-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (20R,22RS)-3β-Acetoxy-14-hydroxy-22-tosyloxymethyl-5β,14β-cardanolid(CAS DataBase Reference)
• NIST Chemistry Reference: (20R,22RS)-3β-Acetoxy-14-hydroxy-22-tosyloxymethyl-5β,14β-cardanolid(61915-17-1)
• EPA Substance Registry System: (20R,22RS)-3β-Acetoxy-14-hydroxy-22-tosyloxymethyl-5β,14β-cardanolid(61915-17-1)

Safety Data

• Hazardous Substances Data: 61915-17-1(Hazardous Substances Data)

Upstream product

• 808-19-5 digitoxigenin 3-acetate 
• 61850-03-1 (20S)-3-O-Acetyl-dihydro-digitoxigenin 
• 143-62-4 (+)-digitoxigenin 
• 61841-76-7 (20R,22RS)-3β-Acetoxy-14-hydroxy-22-hydroxymethyl-5β,14β-cardanolid 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Partial Syntheses of Cardenolides and Cardenolide Analogues. VI. (20R)- and (20S)-Cardanolides

(20R)-Dihydrodigitoxigenin (2) and (20S)-dihydrodigitoxigenin (4) as well as their 3-acetates 3 and 5, respectively, were synthesized by catalytic hydrogenation of the appropriate cardenolides and separation by column chromatography on silica of the mixtures of stereoisomers.Hydroxymethylation of 3 and 5 followed by selective elimination yielded (20S)- and (20R)-14-hydroxy-22-methylene-5β,14β-cardanolide 3-acetate (10 and 16), respectively.The biological activities of the synthesized 20-stereoisomeric cardanolides are investigated and discussed.Cardanolides 10 and 16 have a strong inhibitory activity on the proliferation of Ehrlich ascites carcinoma cells in suspension culture.