621-38-5

Basic information

• Product Name: 3'-BROMOACETANILIDE
• Synonyms: 3'-BROMOACETANILIDE;CHEMBRDG-BB 5475603;3’-bromo-acetanilid;Acetamide, N-(3-bromophenyl)-;Acetanilide, 3'-bromo-;m-bromoacetanilide;n-(3-bromophenyl)-acetamid;3'-Bromoacetoanilide
• CAS NO: 621-38-5
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.06
• Product Categories: Anilines, Amides & Amines;Bromine Compounds
• Mol File: 621-38-5.mol
• Article Data: 65

Chemical Properties

• Melting Point: 87-89 °C
• Boiling Point: 349.2°C at 760 mmHg
• Flash Point: 165°C
• Appearance: /
• Density: 1.5097 (rough estimate)
• Vapor Pressure: 4.77E-05mmHg at 25°C
• Refractive Index: 1.6120 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.45±0.70(Predicted)
• CAS DataBase Reference: 3'-BROMOACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-BROMOACETANILIDE(621-38-5)
• EPA Substance Registry System: 3'-BROMOACETANILIDE(621-38-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 621-38-5(Hazardous Substances Data)

Usage

General Description

3'-Bromoacetanilide is an aromatic compound derived from acetanilide in which a bromine atom has been substituted in the para position of the phenyl ring. It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3'-Bromoacetanilide is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. It is classified as a mild irritant to the skin, eyes, and respiratory system and may cause irritation upon contact. The compound is also considered a potential environmental hazard due to its toxicity to aquatic organisms. Overall, 3'-Bromoacetanilide is a versatile chemical with important applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C8H8BrNO/c1-6(11)10-8-4-2-3-7(9)5-8/h2-5H,1H3,(H,10,11)

Upstream product

• 141-78-6 ethyl acetate 
• 591-19-5 m-Bromoaniline 
• 127-19-5 N,N-dimethyl acetamide 
• 108-24-7 acetic anhydride 
• 585-79-5 m-nitrobromobenzene 
• 13125-68-3 1-bromo-3-nitrosobenzene 
• 431-03-8 dimethylglyoxal 
• 2033-24-1 cycl-isopropylidene malonate 
• 75-05-8 acetonitrile 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 123-54-6 acetylacetone 
• 64-19-7 acetic acid 
• 187672-17-9 (E)-1-(3-bromophenyl)ethan-1-one oxime 
• 24280-05-5 N-[1-(3-bromophenyl)ethylidene]hydroxyl amine 

Downstream Products

• 29551-87-9 acetic acid-(3-bromo-N-chloro-anilide) 
• 37038-71-4 5-Brom-1,2,3,4-tetraphenylnaphthalin 
• 37038-69-0 6-bromo-1,2,3,4-tetraphenylnaphthalene 
• 179251-14-0 2-bromo-4-<(1-oxoethyl)amino>-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide 
• 153624-66-9 2-bromo-4-<(1-oxoethyl)amino>-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide 
• 936092-77-2 N-[3-(2-chloro-5-methyl-pyrimidin-4-ylamino)-phenyl]-acetamide 
• 288156-86-5 4-[3-(methylamidyl)benzoyl]-1-methylpiperidine 
• 104581-30-8 2-methyl-4-(3-acetylaminophenyl)-3-butyn-2-ol 
• 591-19-5 m-Bromoaniline 
• 141417-96-1 N'-(3-bromophenyl)-N-phenylacetimidamide 
• 1627211-59-9 C₁₃H₁₆N₄O₃S 
• 288156-90-1 4-[3-aminobenzoyl]-1-methylpiperidine 
• 22459-83-2 N-(3-bromo-4-chlorophenyl)acetamide 
• 78887-39-5 3-Acetamidophenylboronic acid 

Relevant articles and documents

Z-Selective Fluoroalkenylation of (Hetero)Aromatic Systems by Iodonium Reagents in Palladium-Catalyzed Directed C?H Activation

The direct and catalytic incorporation of fluorine containing molecular motifs into organic compounds resulting high-value added chemicals represents a rapidly evolving part of synthetic methodologies, thus this area is in the focus of pharmaceutical and agrochemical research. Herein we report a stereoselective procedure for direct fluorovinylation of aromatic and heteroaromatic scaffolds. This methodology development has been realized by palladium-catalyzed ortho C?H activation reaction of aniline derivatives featuring the regioselectivity via directing groups such as secondary of tertiary amides, ureas or ketones. The application of non-symmetrical aryl(fluoroalkenyl)-iodonium salts as fluoroalkenylating agents allowed mild reaction conditions in general for this transformation. The scope and limitations have been thoroughly investigated and the feasibility has been demonstrated by more than 50 examples.

Magnetically recyclable silica-coated ferrite magnetite-K10montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions

Novel silica-coated ferrite nanoparticles supported with montmorillonite (K10) have been prepared successfully by using a simple impregnation method. Further, these nanoparticles were characterized by using different analytical methods like FT-IR, PXRD, EDS, and FE-SEM techniques. In addition, these nanoparticles have been explored for their catalytic activity for the O, N, and S-acylation reactions under solvent-free conditions which gave moderate to excellent yields in a much shorter reaction time. Moreover, these nanoparticles could easily be separated out from the reaction medium after the reaction completion by using an external magnetic field and have been re-used for 10 cycles without any significant loss of the catalytic activity.

Ru-Catalyzed C(sp2)?H Bond Arylation of Benzamides Bearing a Novel 4-Aminoantipyrine as a Directing Group

A novel design-based removable N,O-bidentate directing group based on cheap and commercially available 4-aminoantipyrine (AAP) is reported. Aromatic AP amides bearing 4-aminoantipyrine underwent efficient Ru-catalyzed C(sp2)?H arylation using [RuCl2(PPh3)3] as a catalyst and aryl bromides as electrophiles. The novel bidentate directing group enabled the C?H functionalization reaction with good scope, good functional group tolerance and in decent yields.