622-61-7

Basic information

• Product Name: 4-CHLOROPHENETOLE
• Synonyms: P-CHLOROETHOXYBENZENE;P-CHLOROPHENETOLE;1-chloro-4-ethoxy-benzen;1-Ethoxy-chlorobenzene;4-Chlorophenol ethyl ether;Benzene, 1-chloro-4-ethoxy-;benzene,1-chloro-4-ethoxy-;chlorophenentole
• CAS NO: 622-61-7
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.61
• EINECS: 210-747-6
• Product Categories: Phenetole
• Mol File: 622-61-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 17°C
• Boiling Point: 214 °C
• Flash Point: 17 °C
• Appearance: /
• Density: 1,13 g/cm3
• Refractive Index: 1.5240-1.5280
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLOROPHENETOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPHENETOLE(622-61-7)
• EPA Substance Registry System: 4-CHLOROPHENETOLE(622-61-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 622-61-7(Hazardous Substances Data)

Usage

General Description

4-Chlorophenetole, also known as para-chlorophenetole, is a chemical compound with the molecular formula C8H9ClO. It is a colorless liquid with a sweet, floral odor, and it is often used as a fragrance and flavoring agent in various consumer products. 4-Chlorophenetole is also used in the production of perfumes, as well as in the synthesis of other chemicals such as pharmaceuticals and agrochemicals. However, it is important to handle 4-Chlorophenetole with care, as it can be harmful if ingested or inhaled, and it may cause skin and eye irritation upon contact.

InChI:InChI=1/C8H9ClO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 75-03-6 ethyl iodide 
• 106-48-9 4-chloro-phenol 
• 473-29-0 N,N-Dichlorobenzenesulfonamide 
• 107-06-2 1,2-dichloro-ethane 
• 103-73-1 Phenetole 
• 297766-64-4 1,3-Diphenyltriazen 
• 156-43-4 4-Ethoxyaniline 
• 67-64-1 acetone 
• 68714-37-4 triethoxyacetonitrile 
• 64-67-5 diethyl sulfate 
• 7791-25-5 sulfuryl dichloride 
• 10026-13-8 phosphorus pentachloride 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 101574-09-8 bis-(2-ethoxy-5-chloro-phenyl)-methane 
• 156-43-4 4-Ethoxyaniline 
• 5392-86-9 2,4-dichloro-1-ethoxybenzene 
• 23399-88-4 2,4,6-trichlorophenyl ethyl ether 
• 83802-00-0 1,3,4,5,6-pentachloro-4-ethoxycyclohexene 
• 106-48-9 4-chloro-phenol 
• 109514-48-9 2-hydroxy-isophthalic acid-(4-chloro-phenyl ester)-methyl ester 
• 6178-89-8 5,5'-dichloro-2,2'-dihydroxybenzophenone 
• 108904-14-9 2-hydroxy-isophthalic acid mono-(4-chloro-phenyl ester) 
• 101571-55-5 2,2'-diethoxy-5,5'-dichloro-benzophenone 
• 103-73-1 Phenetole 
• 1147105-68-7 2-(4-ethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 645-26-1 (4-ethoxyphenyl) phenyl sulfide 
• 928709-67-5 C₈H₈Cl₂O₃S 

Relevant articles and documents

Efficient halogenation synthesis method of aryl halide

The invention discloses an efficient halogenation synthesis method of aryl halide. The method comprises the following step: in the presence of a catalyst (sulfoxide or oxynitride), a halogenation reagent and a solvent, carrying out a halogenation reaction on an aromatic ring compound to obtain the aryl halide. According to the present invention, in the presence of a catalyst (sulfoxide or nitrogenoxide), a halogenation reagent and a solvent, the aromatic ring is subjected to an efficient halogenation reaction, such that the very useful aryl halide can be obtained with high activity and high selectivity; and by adopting the method disclosed by the invention, aryl halides can be efficiently synthesized, and the method has a wide application prospect in actual production.

Electrophotocatalytic SNAr Reactions of Unactivated Aryl Fluorides at Ambient Temperature and Without Base

The electrophotocatalytic SNAr reaction of unactivated aryl fluorides at ambient temperature without strong base is demonstrated.

Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides

An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.