62227-10-5Relevant articles and documents
Coupling of N-trifluoroacetyl amino acids under 'neutral' conditions.
Benouargha, Amina,Verducci, Jean,Jacquier, Robert
, p. 824 - 828 (2007/10/02)
The possibility of using the trifluoroacetyl group as a base-labile N-protection in peptide synthesis is discussed.Under normal coupling conditions, a very high level of racemization is observed.However, when 'neutral' coupling conditions (by silylation of amino acids or peptides) were used, the coupling racemization decreased as much as 1-2percent. - Key words: peptide coupling; N-protection; N-trifluoroacetyl amino acid; racemization, silylated amino acid
CATALYTIC ASYMMETRIC SYNTHESIS OF DIPEPTIDES FROM 2-TRIFLUOROMETHYL-Δ2- AND 2-TRIFLUOROMETHYL-Δ3-OXAZOLIN-5-ONES
Bitiev, Sh. G.,Chel'tsova, G. V.,Lutsenko, M. R.,Karpeiskaya, E. I.,Klabunovskii, E. I.
, p. 339 - 345 (2007/10/02)
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