62291-64-9

Basic information

• Product Name: Benzene, 1-(cyclohexylthio)-4-nitro-
• Synonyms: 4-cyclohexylsulfanylnitrobenzene;Cyclohexyl-p-nitrophenylsulfid;cyclohexyl-(4-nitro-phenyl)-sulfide;Benzene,1-(cyclohexylthio)-4-nitro;4-(cyclohexylthio)nitrobenzene;Cyclohexyl-(4-nitro-phenyl)-sulfid;cyclohexyl(4-nitrophenyl)sulfane
• CAS NO: 62291-64-9
• Molecular Formula: C12H15NO2S
• Molecular Weight: 237.323
• Mol File: 62291-64-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 53.7-54.8 °C
• Boiling Point: 378.0±25.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-(cyclohexylthio)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(cyclohexylthio)-4-nitro-(62291-64-9)
• EPA Substance Registry System: Benzene, 1-(cyclohexylthio)-4-nitro-(62291-64-9)

Safety Data

• Hazardous Substances Data: 62291-64-9(Hazardous Substances Data)

Upstream product

• 108-85-0 1-bromocyclohexane 
• 824-78-2 4-nitrophenol sodium salt 
• 1849-36-1 para-nitrobenzenethiol 
• 2137-92-0 4-nitrophenyl thiocyanate 
• 108-93-0 cyclohexanol 
• 50729-68-5 sodium cyclohexanethiolate 
• 100-00-5 4-chlorobenzonitrile 
• 1569-69-3 Cyclohexanethiol 
• 62-23-7 4-nitro-benzoic acid 
• 636-98-6 p-nitrobenzene iodide 
• 586-78-7 para-nitrophenyl bromide 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 110-82-7 cyclohexane 
• 2550-40-5 1,2-dicyclohexyl disulfide 

Downstream Products

• 86810-77-7 1-(cyclohexylsulfonyl)-4-nitrobenzene 
• 51170-31-1 (4-aminophenyl)(cyclohexyl)sulfane 

Relevant articles and documents

CuMoO4 Bimetallic Nanoparticles, An Efficient Catalyst for Room Temperature C?S Cross-Coupling of Thiols and Haloarenes

CuII catalyst is less efficient at room temperature for C?S cross-coupling. C?S cross-coupling by CuII catalyst at room temperature is not reported; however, doping of copper with molybdenum metal has been realized here to be more efficient for C?S cross-coupling in comparison to general CuII catalyst. The doped catalyst CuMoO4 nanoparticle is found to be more efficient than copper. The catalyst works under mild conditions without any ligand at room temperature and is recyclable and effective for a wide range of thiols and haloarenes (ArI, ArBr, ArF) from milligram to gram scale. The copper-based bimetallic catalyst is developed and recognized for C?S cross-coupling of haloarenes with alkyl and aryl thiols.

C-S coupling with nitro group as leaving group via simple inorganic salt catalysis

An efficient and practical synthetic protocol to synthesize nonsymmetrical aryl thioethers by nucleophilic aromatic substitution (SNAr) reaction of nitroarenes by thiols with potassium phosphate as the catalyst is described. Various moderate to strong electron-withdrawing functional groups are tolerated by the system to provide thioethers in a good to excellent yields. We also showed that the present method allows access to 3 drug examples in a short reaction time. Finally, mechanistic studies suggest that the reaction may form the classic Meisenheimer complex through a two-step addition-elimination mechanism.

Synthesis of Thioethers and Thioesters with Alkyl Arylsulfinates as the Sulfenylation Agent under Metal-Free Conditions

A study on the coupling of cycloalkanes with alkyl arylsulfinates has been performed. Using iodine as the catalyst, through C (Formula presented.) ?H bond activation and sulfinates reduction, a wide range of thioethers were produced in moderate to high yields. Additionally, various thiocarboxylic esters can also be produced by simply performing the reaction under CO pressure. Notably, this is the first report in which alkyl arylsulfinates were used as sulfenylation agents in a cross-coupling transformation.