62346-09-2Relevant articles and documents
Extended scaffold glucuronides: En route to the universal synthesis of O -aryl glucuronide prodrugs
Walther, Raoul,Jarlstad Olesen, Morten T.,Zelikin, Alexander N.
, p. 6970 - 6974 (2019)
We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.