6250-88-0

Basic information

• Product Name: 4,9-dihydropyrano[3,4-b]indol-1(3H)-one
• Synonyms: 4,9-Dihydropyrano[3,4-b]indol-1(3H)-one
• CAS NO: 6250-88-0
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.1947
• Mol File: 6250-88-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 461.9°C at 760 mmHg
• Flash Point: 233.1°C
• Density: 1.373g/cm³
• Vapor Pressure: 1.04E-08mmHg at 25°C
• Refractive Index: 1.696
• CAS DataBase Reference: 4,9-dihydropyrano[3,4-b]indol-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,9-dihydropyrano[3,4-b]indol-1(3H)-one(6250-88-0)
• EPA Substance Registry System: 4,9-dihydropyrano[3,4-b]indol-1(3H)-one(6250-88-0)

Safety Data

• Hazardous Substances Data: 6250-88-0(Hazardous Substances Data)

Usage

General Description

4,9-dihydropyrano[3,4-b]indol-1(3H)-one is a chemical compound with a molecular formula of C13H9NO2. It is a heterocyclic compound featuring a pyran ring fused to an indole ring, and a lactone functional group. 4,9-dihydropyrano[3,4-b]indol-1(3H)-one is commonly used as a building block in organic synthesis and pharmaceutical research, due to its versatile reactivity and potential therapeutic applications. It has been studied for its pharmacological properties, including its potential as an anti-cancer and anti-inflammatory agent. Its unique structure and biological activity make it a valuable target for chemical and pharmaceutical research.

Upstream product

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Downstream Products

• 89587-10-0 2,3,4,9-Tetrahydro-2-phenyl-1H-pyrido<3,4-b>indol-1-one 
• 111550-69-7 3-(2-Hydroxyethyl)-N-methyl-1H-indole-2-carboxamide 
• 59156-98-8 Strychnocarpine 
• 111492-86-5 N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one 
• 77903-96-9 3-(2-Hydroxyethyl)-1H-indole-2-carboxylic acid 
• 125260-52-8 3-[2-(4-methylpiperidin-1-yl)ethyl]-1H-indole 
• 129697-29-6 3-[2-(2,3-dihydro-1H-indol-1-yl)ethyl]-1H-indole 
• 61220-24-4 1-[1-(2-indol-3-yl-ethyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one 
• 61-51-8 N,N-diethyltryptamine 
• 14120-99-1 N-benzyl-[2-(1H-indol-3-yl)ethyl]-N-methylamine 

Relevant articles and documents

Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds

Glucagon-like peptide-1 (GLP-1), which belongs to the family of incretins, plays important role for the regulation of plasma glucose. Accordingly, GLP-1-based therapies for type 2 diabetes have recognized as one of the most interesting target. In this study, we have found the new tricyclic compounds having strong GLP-1 secretion from human intestinal L cells, and anti-diabetic properties in spontaneously obese and diabetic KKAy mice. The most potent compound 5ka was obtained as the unexpected product, and we would like to report the details of the synthesis, structure elucidations, pharmacological activities on secretion of GLP-1, and anti-diabetic effects using diabetic KKAy mice.

Lactones, XI: Syntheses of 4,9-Dihydropyrano-indol-1(3H)-ones from &α-Ethoxalyl-&γ-lactones

Cleavage and decarboxylation of the α-ethoxalyl-γ-lactones 1a-d followed by treatment with phenylhydrazines yield the hydrazones 4a-l, which can be rearranged to the indololactones 5a-m.Starting from the δ-lactones 6 and 10, the same reactions lead to indoles without lactone ring closure.