6265-30-1

Basic information

• Product Name: 3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aalpha,4alpha,7alpha,7aalpha)-
• CAS NO: 6265-30-1
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.176
• Mol File: 6265-30-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 362.1°Cat760mmHg
• Flash Point: 177.1°C
• Density: 1.339g/cm³
• CAS DataBase Reference: 3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aalpha,4alpha,7alpha,7aalpha)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aalpha,4alpha,7alpha,7aalpha)-(6265-30-1)
• EPA Substance Registry System: 3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aalpha,4alpha,7alpha,7aalpha)-(6265-30-1)

Safety Data

• Hazardous Substances Data: 6265-30-1(Hazardous Substances Data)

Usage

General Description

3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aalpha,4alpha,7alpha,7aalpha)- is a chemical compound with the molecular formula C9H9NO2. It is a cyclic organic compound with a tetrahydro-1H-isoindole-1,3-dione structure. 3a,4,7,7a-Tetrahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aalpha,4alpha,7alpha,7aalpha)- is primarily used in pharmaceutical research and drug development, where it may have potential applications as a therapeutic agent due to its unique chemical structure. Additionally, it may also have uses in other industries, such as in the development of new materials or as a chemical intermediate in organic synthesis. Further research may reveal additional potential applications and benefits for this compound.

Upstream product

• 541-59-3 maleiimide 
• 542-92-7 cyclopenta-1,3-diene 
• 129-64-6 3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride 
• 42867-30-1 Silver maleimide 
• 61800-55-3 endo-5-carbamoylbicyclo[2.2.1]hept-2-ene-endo-6-carboxylic acid 

Downstream Products

• 5263-68-3 (1α,2α,6α,7α)-4-azatricyclo[5.2.1.0^2,6]dec-8-ene 
• 1187583-61-4 C₂₃H₂₈ClN₃O₂ 
• 1187583-62-5 C₂₃H₂₈ClN₃O₂ 
• 1187583-63-6 C₂₄H₃₁N₃O₂ 
• 1187583-64-7 C₂₄H₃₁N₃O₂ 
• 1187583-60-3 4-[4-(4-phenylpiperazin-1-yl)butyl]-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione 
• 1609464-87-0 2-{4-[3-(trifluoromethyl)phenyl]piperazinylbutyl}-4,7-endomethylene-1H-isoindole 
• 14805-29-9 (3aR,4S,7R,7aS)?4,7?methylene?1H?isoindole?1,3(2H)-dione 
• 75715-21-8 (1α,2α,6α,7α)-4-benzyl-4-azatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 
• 78087-47-5 (1S,2R,6S,7R)-4-Benzenesulfonyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene 
• 78028-14-5 N-chloroacetyl-4-azatricyclo<5.2.1.0^2,6>dec-8-ene 

Relevant articles and documents

-

-

Pyrrolidine synthesis on polystyrene supports: Development of a 'one-pot' dipolar cycloaddition strategy

Preparation of substituted pyrrolidines was achieved by solid-phase synthesis via a room temperature 1,3-dipolar cycloaddition of a silver-azomethine ylide, generated in situ, with a polymer-supported maleimide.

PROCESS FOR THE INDUSTRIAL SYNTHESIS OF LURASIDONE

Disclosed is a process for the industrial synthesis of Lurasidone from (1R,2R)-cyclohexane-1,2-diyldimethanol (1), 3-(piperazin-1- yl)benzo[d]isothiazole (3) and (3aR,4R,7R,7aS)-3a,4,7,7a-tetrahydro-4,7- methanoisobenzofuran-1,3-dione (6).). Said process is optimised to obtain Lurasidone with high yields and high purities by preparing highly pure synthesis intermediates, using critical raw materials and reagents in amounts close to the stoichiometric amounts, increasing productivity and reducing the costs and environmental impact of the process.

IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions

The first o-iodoxybenzoic acid (IBX) mediated oxidation of unactivated amines to imines is described. A range of meso-pyrrolidines were shown to be suitable substrates. The chemical space was further explored with one-pot oxidative Ugi-type and aza-Friedel-Crafts reactions, which proved to be highly diastereoselective.