628279-21-0Relevant articles and documents
Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase
Foley, Louise H.,Wang, Ping,Dunten, Pete,Ramsey, Gwendolyn,Gubler, Mary-Lou,Wertheimer, Stanley J.
, p. 3607 - 3610 (2007/10/03)
The first non-substrate like inhibitors of human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) competitive with GTP are reported. An effort to discover orally active compounds that improve glucose homeostasis in Type 2 diabetics by reversibly inhibi