6287-89-4

Basic information

• Product Name: 2-(2-methoxyphenoxy)pyridine
• Synonyms: 2-(2-methoxyphenoxy)pyridine
• CAS NO: 6287-89-4
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22124
• EINECS: 228-524-7
• Mol File: 6287-89-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 309.5°C at 760 mmHg
• Flash Point: 113.5°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-(2-methoxyphenoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxyphenoxy)pyridine(6287-89-4)
• EPA Substance Registry System: 2-(2-methoxyphenoxy)pyridine(6287-89-4)

Safety Data

• Hazardous Substances Data: 6287-89-4(Hazardous Substances Data)

Usage

General Description

2-(2-methoxyphenoxy)pyridine is a chemical compound with the molecular formula C12H11NO2. It is a pyridine derivative with a methoxyphenyl group attached to the second carbon of the pyridine ring. 2-(2-methoxyphenoxy)pyridine is used as a building block in organic synthesis and pharmaceutical research. It has the potential to be utilized in the development of new drugs and agrochemicals due to its unique structure and properties. Additionally, 2-(2-methoxyphenoxy)pyridine may have applications in the field of materials science, such as in the synthesis of novel polymers or as a component in the production of specialty chemicals. Its chemical properties make it a versatile and valuable compound in various scientific and industrial applications.

InChI:InChI=1/C12H11NO2/c1-14-10-6-2-3-7-11(10)15-12-8-4-5-9-13-12/h2-9H,1H3

Upstream product

• 121899-81-8 tris(2-methoxyphenyl)bismuth dichloride 
• 142-08-5 2-Pyridone 
• 1421781-41-0 2-methoxyphenyl picolinate 
• 67-56-1 methanol 
• 4783-68-0 2-phenoxypyridine 
• 90-05-1 2-methoxy-phenol 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 100-66-3 methoxybenzene 
• 107455-62-9 N-(2-methoxyphenyl)-4-methylaniline 
• 1590346-18-1 pentyl 3-methoxy-2-(pyridin-2-yloxy)benzoate 

Relevant articles and documents

Palladium-catalyzed direct C(sp2)-H alkoxylation of 2-aryloxypyridines using 2-pyridyloxyl as the directing group

An efficient and highly regioselective palladium-catalyzed ortho-C(sp2)-H bond alkoxylation of 2-aryloxypyridines was developed using 2-pyridyloxyl as the directing group and alcohols as alkoxylation reagents. Under an air atmosphere and in the presence of PhI(OAc)2, the reaction gave the corresponding products in moderate to good yields, and a series of functional groups could be tolerated.

A directing group-assisted ruthenium-catalyzed approach to access: Meta -nitrated phenols

meta-Selective C-H nitration of phenol derivatives was developed using a Ru-catalyzed σ-activation strategy. Cu(NO3)2·3H2O was employed as the nitrating source, whereas Ru3(CO)12 was found to be the most suitable metal catalyst for the protocol. Mechanistic studies suggested involvement of an ortho-CAr-H metal intermediate, which promoted meta-electrophilic aromatic substitution and silver-assisted free-radical pathway.

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Because diaryl ethers are present as an important motif in pharmaceuticals and natural products, extensive studies for the development of novel methods have been conducted. A conventional method for the construction of the diaryl ether moiety is the intermolecular cross-coupling reaction of aryl halides and phenols with a copper or palladium catalyst. We developed a catalytic decarbonylative etherification of aromatic esters using a palladium or nickel catalyst with our enabling diphosphine ligand to give the corresponding diaryl ethers. The present reaction can be conducted on gram scale in excellent yield. This reaction not only functions in an intramolecular setting but also allows for a cross-etherification using other phenols.