6290-49-9Relevant articles and documents
KINETICS OF ESTERIFICATION OF METHOXYACETIC ACID BY METHANOL
Avrutskii, M. M.,Balyakina, M. V.,Beregovykh, V. V.,Gunar, V. I.
, p. 912 - 915 (1982)
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Cobalt-catalyzed Hydroesterification of Formaldehyde Dialkyl Acetals
Murata, Kazuhisa,Matsuda, Akio,Masuda, Takashi
, p. 2141 - 2142 (1985)
Co2(CO)8-organic amine system was found to be an effective catalyst for the production of alkoxyacetic ester from formaldehyde dialkyl acetals and CO; this is the first example of homogeneous hydroesterification of acetals.
Preparation method of 4-alkoxyacetoacetate compound
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Paragraph 0044-0045; 0048-0049; 0052-0053; 0056-0057; 0060, (2020/04/22)
The invention discloses a preparation method of a 4-alkoxyacetoacetate compound, and the method comprises the following steps: reacting a compound I with a first alkali in a first solvent to obtain anintermediate II; reacting the intermediate II obtained in the step (1) with a second alkali in a second solvent to obtain an intermediate III; reacting the intermediate III obtained in the step (2) in an aqueous solution of acid to obtain a product IV, namely the 4-alkoxyacetoacetate compound, wherein X is chlorine, bromine or iodine; wherein R is a C1-C4 alkyl group and a derivative thereof. Thepreparation method provided by the invention has the advantages of simple steps, mild conditions, environmental friendliness, cheap and easily available raw materials, stable supply and low cost, andcreates favorable conditions for reducing the raw material cost of dolutegravir.
Excellent prospects in methyl methoxyacetate synthesis with a highly active and reusable sulfonic acid resin catalyst
Chen, Fei,Shi, Lei,Bello, SuleimanSabo,Fan, Jiaqi,Wang, Yan,Zhang, Dongxi,Yao, Jie
, p. 1346 - 1353 (2020/02/04)
Methyl methoxyacetate (MMAc) is a significant chemical product and can be applied as a gasoline and diesel fuel additive. This study aimed to achieve the industrial production of MMAc via dimethoxymethane (DMM) carbonylation. The effects of industrial DMM sources, reaction temperature, water content, pretreatment temperature, reaction pressure and time, the ratio of CO to DMM and recycle times were systematically investigated without any solvent. The conversion of DMM was 99.98% with 50.66% selectivity of MMAc at 393 K, 6.0 MPa reaction pressure, with the ratio of CO to DMM of only 1.97/1. When water was extracted from the DMM reactant, the MMAc selectivity significantly rose to 68.83%. This resin catalyst was reused for more than nineteen times in a slurry phase reactor and continuously performed for 300 h without noticeable loss of activity in a fixed bed reactor, displaying excellent stability. The mixed products were successfully separated by distillation, and 99.18% purity of MMAc was obtained. Therefore, the reported DMM carbonylation to MMAc process has an excellent basis for industrial application.
The MOF-driven synthesis of supported palladium clusters with catalytic activity for carbene-mediated chemistry
Fortea-Pérez, Francisco R.,Mon, Marta,Ferrando-Soria, Jesús,Boronat, Mercedes,Leyva-Pérez, Antonio,Corma, Avelino,Herrera, Juan Manuel,Osadchii, Dmitrii,Gascon, Jorge,Armentano, Donatella,Pardo, Emilio
, p. 760 - 766 (2017/07/04)
The development of catalysts able to assist industrially important chemical processes is a topic of high importance. In view of the catalytic capabilities of small metal clusters, research efforts are being focused on the synthesis of novel catalysts bearing such active sites. Here we report a heterogeneous catalyst consisting of Pd4 clusters with mixed-valence 0/+1 oxidation states, stabilized and homogeneously organized within the walls of a metal-organic framework (MOF). The resulting solid catalyst outperforms state-of-the-art metal catalysts in carbene-mediated reactions of diazoacetates, with high yields (>90%) and turnover numbers (up to 100,000). In addition, the MOF-supported Pd4 clusters retain their catalytic activity in repeated batch and flow reactions (>20 cycles). Our findings demonstrate how this synthetic approach may now instruct the future design of heterogeneous catalysts with advantageous reaction capabilities for other important processes.