630-94-4 Usage
Description
Corynoxeine is an alkaloid that is isolated from the extraction of Uncaria rhynchophylla, a plant species known for its medicinal properties. It is recognized for its potential therapeutic effects, particularly in the realm of vascular health and neuroprotection.
Uses
Used in Pharmaceutical Industry:
Corynoxeine is used as a therapeutic agent for the treatment of vascular diseases, leveraging its ability to improve vascular function and overall cardiovascular health.
Used in Neuroprotective Applications:
In the field of neurology, corynoxeine serves as a neuroprotective agent, specifically aimed at protecting against ischemia-induced neuronal damage. This makes it a valuable compound in the development of treatments for conditions associated with reduced blood flow and oxygen supply to the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 630-94-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 630-94:
(5*6)+(4*3)+(3*0)+(2*9)+(1*4)=64
64 % 10 = 4
So 630-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8,13-15,19H,1,9-12H2,2-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1
630-94-4Relevant articles and documents
Total synthesis of the spirocyclic oxindole alkaloids corynoxine, corynoxine B, corynoxeine, and rhynchophylline
Wanner, Martin J.,Ingemann, Steen,Van Maarseveen, Jan H.,Hiemstra, Henk
, p. 1100 - 1106 (2013/03/29)
Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N-2-butenylated 2-hydroxytryptamine, which underwent a base-mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C-ring. The second key step was a Pd-catalysed cyclisation of an α-keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N-substituent) to form the D-ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time. Racemic total syntheses of the four title spirocyclic oxindole alkaloids are reported starting from 4-hydroxytryptamine. The key steps were a base-mediated Mannich spirocyclisation to form the C-ring, and a Pd-catalysed cyclisation of a keto ester enolate onto an allylic carbonate to form the D-ring. Thus, convenient syntheses of the alkaloids were achieved, for three of them for the first time. Copyright
