631-06-1

Basic information

• Product Name: Dexoxadrol
• Synonyms: D-2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidine hydrochloride;D-2,2-Diphenyl-4-(2-piperidyl)-1,3-dioxolane hydrochloride;D-Dioxadrol hydrochloride;Dexoxadrol HCl
• CAS NO: 631-06-1
• Molecular Formula: C₂₀H₂₃NO₂*ClH
• Molecular Weight: 345.90
• Mol File: 631-06-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 248-254 °C
• Boiling Point: 441.9°C at 760 mmHg
• Flash Point: 187.1°C
• Appearance: /
• Vapor Pressure: 5.26E-08mmHg at 25°C
• CAS DataBase Reference: Dexoxadrol(CAS DataBase Reference)
• NIST Chemistry Reference: Dexoxadrol(631-06-1)
• EPA Substance Registry System: Dexoxadrol(631-06-1)

Safety Data

• Hazardous Substances Data: 631-06-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H23NO2.ClH/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18;/h1-6,9-12,18-19,21H,7-8,13-15H2;1H/t18-,19+;/m0./s1

Upstream product

• 2235-01-0 dimethoxydiphenylmethane 
• 117994-55-5 (βS,2S)-β-hydroxypiperidin-2-ethanol 
• 4741-41-7 dexoxadrol 
• 1514644-66-6 (S)-benzyl-2-vinylpiperidine-1-carboxylate 

Relevant articles and documents

A concise diastereoselective approach to (+)-dexoxadrol, (-)-epi-dexoxadrol, (-)-conhydrine and (+)-lentiginosine from (-)-pipecolinic acid

A new diastereoselective pathway for the total synthesis of (+)-dexoxadrol, first asymmetric synthesis of (-)-epi-dexoxadrol and formal synthesis of conhydrine and (+)-lentiginosine is presented using commercially available (-)-pipecolinic acid. The key reactions utilized are Sharpless asymmetric dihydroxylation and Wittig reaction. The paper further describes the study of effect of protecting groups on dihydroxylation of a terminal olefin in piperidine ring system.