63224-15-7

Basic information

• Product Name: N-[2-(dimethylamino)ethyl]propanamide
• CAS NO: 63224-15-7
• Molecular Formula: C₇H₁₆N₂O
• Molecular Weight: 144.2147
• Mol File: 63224-15-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 264.2°C at 760 mmHg
• Flash Point: 113.6°C
• Density: 0.916g/cm³
• Vapor Pressure: 0.00982mmHg at 25°C
• Refractive Index: 1.444
• CAS DataBase Reference: N-[2-(dimethylamino)ethyl]propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(dimethylamino)ethyl]propanamide(63224-15-7)
• EPA Substance Registry System: N-[2-(dimethylamino)ethyl]propanamide(63224-15-7)

Safety Data

• Hazardous Substances Data: 63224-15-7(Hazardous Substances Data)

Upstream product

• 107-99-3 2-(dimethylamino)ethyl chloride 
• 802294-64-0 propionic acid 
• 108-00-9 N,N-dimethylethylenediamine 
• 79-03-8 propionyl chloride 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 63224-24-8 N-(2-(dimethylamino)ethyl)-3-phenylpropanamide 

Relevant articles and documents

INFLUENCE OF THE CONFORMATION OF AMIDE ANALOGS OF ACETYLCHOLINE ON THEIR CHOLINOMIMETIC ACTIVITY

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A Simple Aliphatic Diamine Auxiliary for Palladium-Catalyzed Arylation of Unactivated β-C(sp3)-H Bonds

Palladium-catalyzed β-C(sp3)-H arylation of aliphatic acid derivatives was achieved by means of 2-dimethylaminoethylamine auxiliary as a directing group. The β-C(sp3)-H arylation reactions with aryl and heteroaryl iodides efficiently afforded the corresponding arylated hydrocinnamic acid derivatives. Direct β-C(sp3)-H alkynylation, and arene C?H arylation and alkynylation were also realized under the same or slightly modified conditions. The aliphatic diamine auxiliary in the products could be readily removed by methanol in the presence of BF3 ? OEt2. In comparison with the widely used bidentate nitrogen-containing directing groups, 2-dimethylaminoethylamine is a simple, cheap, readily available and removable, and atom-economical directing group for C?H functionalization. (Figure presented.).